Ling Xu
Kunming Institute of Zoology
41 Papers
149 Citations
Ling Xu is an academic researcher from Kunming Institute of Zoology. The author has contributed to research in topics: Phylogenetic tree & Biology. The author has an hindex of 12, co-authored 36 publications. Previous affiliations of Ling Xu include Chinese Academy of Sciences & The Chinese University of Hong Kong.
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Papers
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
Jingxin Qiao,Y. Li,Rui Zeng,Feng-Liang Liu,Rong-Hua Luo,Chong Huang,Yifei Wang,Jie Zhang,Baoxue Quan,Chenjian Shen,Xin Mao,Xinlei Liu,Weining Sun,Wei Yang,Xincheng Ni,Kai Wang,Ling Xu,Zilei Duan,Qing-Cui Zou,Hai-Lin Zhang,Qu Wang,Yang-Hao-Peng Long,Ming-Hua Li,Rui-Cheng Yang,Xiaolong Liu,Jing You,Yangli Zhou,Rui Yao,Wen-Pei Li,Jing-Ming Liu,Pei Chen,Yang Liu,Guifeng Lin,Xin Yang,Jun Zou,Lin-Li Li,Yiguo Hu,Guangwen Lu,Weimin Li,Yuquan Wei,Yong-Tang Zheng,Jian Lei,Shengyong Yang +42 more
TL;DR: In this article, the main protease (Mprotease) of SARS-CoV-2 plays a central role in viral replication, and 32 bicycloproline-containing Mpro inhibitors derived from either boceprevir or telaprevir were designed and synthesized.
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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target.
Bingqing Xia,Xurui Shen,Yang He,Xiaoyan Pan,Feng-Liang Liu,Yi Wang,Feipu Yang,Sui Fang,Yan Wu,Zilei Duan,Xiaoli Zuo,Zhuqing Xie,Zhuqing Xie,Xiangrui Jiang,Ling Xu,Hao Chi,Shuang-Qu Li,Qian Meng,Hu Zhou,Yubo Zhou,Xi Cheng,Xiaoming Xin,Lin Jin,Hai-Lin Zhang,Dan dan Yu,Ming-Hua Li,Xiao Li Feng,Jiekai Chen,Hualiang Jiang,Gengfu Xiao,Yong-Tang Zheng,Lei Ke Zhang,Jingshan Shen,Jia Li,Zhaobing Gao +34 more
TL;DR: In this article, the authors showed that the SARS-CoV-2 envelope (2-E) protein alone is able to cause acute respiratory distress syndrome (ARDS)-like damages in vitro and in vivo.
Evaluating the phylogenetic position of Chinese tree shrew (Tupaia belangeri chinensis) based on complete mitochondrial genome: implication for using tree shrew as an alternative experimental animal to primates in biomedical research.
TL;DR: The mtDNA genomes of Chinese tree shrews and Malayan flying lemur shared similar gene organization and structure with those of other mammals, suggesting that the matrilineal affinity of tree shrew to primates may not be as close as previously thought.
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COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2.
Ling Xu,Dandan Yu,Ma Yuhua,Yu-Lin Yao,Yu-Lin Yao,Rong-Hua Luo,Xiao-Li Feng,Hou-Rong Cai,Jian-Bao Han,Xue-Hui Wang,Xue-Hui Wang,Ming-Hua Li,Chang-Wen Ke,Yong-Tang Zheng,Yong-Gang Yao +14 more
TL;DR: The results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection, and several differences were found between the two different aged groups in regard to viral shedding peak.
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Chromosomal level assembly and population sequencing of the Chinese tree shrew genome.
Yu Fan,Mao-Sen Ye,Mao-Sen Ye,Jin-Yan Zhang,Jin-Yan Zhang,Ling Xu,Ling Xu,Dandan Yu,Dandan Yu,Tianle Gu,Tianle Gu,Yu-Lin Yao,Yu-Lin Yao,Jia-Qi Chen,Longbao Lv,Ping Zheng,Dong-Dong Wu,Dong-Dong Wu,Guojie Zhang,Guojie Zhang,Yong-Gang Yao +20 more
TL;DR: The new high-quality reference genome of the Chinese tree shrew and the updated TreeshrewDB will facilitate the use of this animal in many different fields of research.
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