Ling Meng
University of Florida
20 Papers
20 Citations
Ling Meng is an academic researcher from University of Florida. The author has contributed to research in topics: Aptamer & Systematic evolution of ligands by exponential enrichment. The author has an hindex of 12, co-authored 19 publications. Previous affiliations of Ling Meng include McKnight Brain Institute.
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Papers
Cell-specific aptamer probes for membrane protein elucidation in cancer cells.
Dihua Shangguan,Zehui Cao,Ling Meng,Prabodhika Mallikaratchy,Kwame Sefah,Hui Wang,Ying Li,Weihong Tan +7 more
TL;DR: This two-step strategy, that is, first selecting cancer cell-specific aptamers and then identifying their binding target proteins, has major clinical implications in that the technique promises to substantially improve the overall effectiveness of biomarker discovery.
Molecular recognition of small-cell lung cancer cells using aptamers.
Hui William Chen,Colin D. Medley,Kwame Sefah,Dihua Shangguan,Zhiwen Tang,Ling Meng,Josh E. Smith,Weihong Tan +7 more
TL;DR: The developed new aptamer approach for the recognition of specific small‐cell lung cancer (SCLC) cell‐surface molecular markers relies on cell‐based systematic evolution of ligands by exponential enrichment (cell‐SELEX) to evolve aptamers for whole live cells that express a variety of surface markers representing molecular differences among cancer cells.
Molecular recognition of acute myeloid leukemia using aptamers.
Kwame Sefah,Zhiwen Tang,Dihua Shangguan,Hui William Chen,Dalia Lopez-Colon,Y Li,Parag Parekh,Jennifer A. Martin,Ling Meng,Joseph A. Phillips,Youngmi Kim,Weihong Tan,Weihong Tan +12 more
TL;DR: In this article, the authors used live acute myeloid leukemia (AML) cells to select a group of DNA aptamers, which can recognize AML cells with dissociation constants (Kd's) in the nanomolar range.
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Nucleic acid aptamers for biosensors and bio-analytical applications
Kwame Sefah,Joseph A. Phillips,Xiangling Xiong,Ling Meng,Dimitri Van Simaeys,Hui Chen,Jennifer A. Martin,Weihong Tan +7 more
TL;DR: The robust nature of oligonucleotides, in terms of synthesis, storage, and wide range of temperature stability and chemical manipulation, makes them highly suitable for biosensor design and engineering.
194
Targeted delivery of chemotherapy agents using a liver cancer-specific aptamer.
TL;DR: This study incorporated the antitumor agent Doxorubicin into the modified DNA aptamer TLS11a-GC, which specifically targets LH86, a human hepatocellular carcinoma cell line, and demonstrated both potency and target specificity.