Ling Chen
Fujian Medical University
6 Papers
14 Citations
Ling Chen is an academic researcher from Fujian Medical University. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Ling Chen include University of Maryland, Baltimore & Sun Yat-sen University.
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Papers
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
Jun Wang,Miguel F. Sanmamed,Ila Datar,Tina Tianjiao Su,Lan Ji,Jingwei Sun,Ling Chen,Yusheng Chen,Gefeng Zhu,Weiwei Yin,Linghua Zheng,Ting Zhou,Ti Badri,Sheng Yao,Shu Zhu,Agedi Boto,Mario Sznol,Ignacio Melero,Dario A. A. Vignali,Kurt A. Schalper,Lieping Chen,Lieping Chen +21 more
TL;DR: It is demonstrated that fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II, revealing an immune evasion mechanism and have implications for the design of cancer immunotherapy.
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B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction.
TL;DR: It is shown that immunization with multiple tumor Ag-loaded DCs, in the absence of B7-H1, vastly enhances cytotoxic T lymphocyte (CTL) responses to dominant Ag, in sharp contrast, CTL responses to subdominant Ag were paradoxically suppressed, facilitating outgrowth of tumor variants carrying only subDominant Ag.
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Herpesvirus entry mediator regulates hypoxia-inducible factor–1α and erythropoiesis in mice
Yukimi Sakoda,Sudarshan Anand,Yuming Zhao,Jang-June Park,Yingjia Liu,Atsuo Kuramasu,Atsuo Kuramasu,Nico van Rooijen,Ling Chen,Scott E. Strome,Wayne W. Hancock,Lieping Chen,Koji Tamada,Koji Tamada +13 more
TL;DR: Signaling through herpesvirus entry mediator (HVEM), a molecule of the TNF receptor superfamily, promoted HIF-1α activity in the kidney and subsequently facilitated renal Epo production and erythropoiesis in vivo under normoxic conditions, suggesting this molecular mechanism could represent a therapeutic target for Epo-responsive diseases, including anemia.
CD8+ T cell/cancer-associated fibroblast ratio stratifies prognostic and predictive responses to immunotherapy across multiple cancer types
Xinlong Zheng,Kan Jiang,Weijin Xiao,Dongqiang Zeng,Wenying Peng,Jing Bai,Xiaohui Chen,Pansong Li,Longfeng Zhang,Xiaobing Zheng,Qian Miao,Haibo Wang,Shiwen Wu,Yiquan Xu,Haipeng Xu,Chao Li,Lifeng Li,Xuan Gao,Suya Zheng,Junhui Li,Deqiang Wang,Zhi Rui Zhou,Xuefeng Xia,Shanshan Yang,Yujing Li,Zhaolei Cui,Qiuyu Zhang,Ling Chen,Xiandong Lin,Gen Lin +29 more
TL;DR: In this paper , the CD8+ T cell/CAF ratio (CFR) association with survival was investigated in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) lung cancer cohorts.
Risk factors of significant relapse and appropriate maintenance therapy strategy in SLE-associated immune thrombocytopenia
TL;DR: In this paper , the authors used multivariate logistic regression models to determine the risk factors for relapse and appropriate maintenance therapy in significant SLE-ITP patients (a platelet count ⩽30××109/l) after the first complete response.
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