Degradable and cell-compatible hydrogels can be designed to mimic the physical and biochemical characteristics of native extracellular matrices and provide tunability of degradation rates and related properties under physiological conditions. Hence, such hydrogels are finding widespread application in many bioengineering fields, including controlled bioactive molecule delivery, cell encapsulation for controlled three-dimensional culture, and tissue engineering. Cellular processes, such as adhesion, proliferation, spreading, migration, and differentiation, can be controlled within degradable, cell-compatible hydrogels with temporal tuning of biochemical or biophysical cues, such as growth factor presentation or hydrogel stiffness. However, thoughtful selection of hydrogel base materials, formation chemistries, and degradable moieties is necessary to achieve the appropriate level of property control and desired cellular response. In this review, hydrogel design considerations and materials for hydrogel preparation, ranging from natural polymers to synthetic polymers, are overviewed. Recent advances in chemical and physical methods to crosslink hydrogels are highlighted, as well as recent developments in controlling hydrogel degradation rates and modes of degradation. Special attention is given to spatial or temporal presentation of various biochemical and biophysical cues to modulate cell response in static (i.e., non-degradable) or dynamic (i.e., degradable) microenvironments. This review provides insight into the design of new cell-compatible, degradable hydrogels to understand and modulate cellular processes for various biomedical applications.

https://pubs.rsc.org/en/content/articlepdf/2013/cs/c3cs60040h

Designing degradable hydrogels for orthogonal control of cell microenvironments

pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium.

http://www.ics-cnrs.unistra.fr/Mcube/mcube_data/marques_articles/107.pdf

Gel-Assisted Formation of Giant Unilamellar Vesicles

An overview on the mathematical modeling of hydrogels' behavior for drug delivery systems.

We report the development of a new type of hydrogel in which a cosolvent has been added to the water component. The gel networks are based on the well-known poly(vinyl alcohol)−borate systems (PVA−borate). However, it is shown that the rheological and solubilizing properties of the hydrogels can be modified drastically by the addition of a cosolvent. The studies have focused on 1-propanol as the added liquid, although it is shown that others (propylene carbonate, 1-pentanol, cyclohexanone, and 2-butanol) are amenable to making modified hydrogels as well. In addition to the rheological measurements, the gels have been investigated by differential scanning calorimetry (free water index) and determination of their solubilizing power. Finally, the gels have been applied to clean and oxidized varnish (patina) from the surface of a XVI−XVII century oil-on-wood painting by Ludovico Cardi detto il Cigoli. The mode of cleaning by and removal of the PVA−borate water/1-propanol gel from the painted surface demonstra...

Poly(vinyl alcohol)—Borate Hydro/Cosolvent Gels: Viscoelastic Properties, Solubilizing Power, and Application to Art Conservation

Modifying the release of proxyphylline from PVA hydrogels using surface crosslinking

In this work, we present a mathematical model for the simulation of water uptake by and drug release from homogeneous hydrogels. This model successfully predicts the shape of the water uptake profile (including Super Case II transport) as well as the initial burst release observed experimentally in homogeneous poly(vinyl alcohol) hydrogels. Parameter sensitivity studies were performed on the modeling of homogeneous hydrogels, showing the polymer relaxation constant had a profound effect on water uptake and drug release.

Mathematical Model to Predict Drug Release, Including the Early-Time Burst Effect, from Swellable Homogeneous Hydrogels

Surface crosslinking for delayed release of proxyphylline from PHEMA hydrogels.

In this paper, we extend a mathematical model previously proposed for drug release from homogeneous swellable hydrogels to surface cross-linked hydrogels. This new model predicts the simultaneous water uptake into and drug diffusion from a cross-linked hydrogel with a bulk inner core surrounded by a highly cross-linked surface layer. The model verifies our experimental work to show that the treatment of surface cross-linking can be used to reduce the initial burst observed in homogeneous poly(vinyl alcohol) hydrogels and achieve near zero-order release. In the model, the parameter that has the greatest impact on reduced burst release is the water partition coefficient between the surface cross-linked and bulk layers.

Theoretical Verification of Surface Cross-Linking as an Effective Method To Reduce Initial Burst Release from Swellable Hydrogels

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Linfeng Wu

Author Tools

Chat about Author

Papers

Modifying the release of proxyphylline from PVA hydrogels using surface crosslinking

Mathematical Model to Predict Drug Release, Including the Early-Time Burst Effect, from Swellable Homogeneous Hydrogels

Surface crosslinking for delayed release of proxyphylline from PHEMA hydrogels.

Theoretical Verification of Surface Cross-Linking as an Effective Method To Reduce Initial Burst Release from Swellable Hydrogels