Lindsay C. Ward
St James's University Hospital
5 Papers
8 Citations
Lindsay C. Ward is an academic researcher from St James's University Hospital. The author has contributed to research in topics: Cancer & Wnt signaling pathway. The author has an hindex of 4, co-authored 5 publications.
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Papers
Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
TL;DR: Using gene expression signatures, this paper identified major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival, and devised an in-silico strategy to map patterns of pathway activation in 301 primary gastric cancers, the second highest cause of global cancer mortality.
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Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
- 01 Oct 2009
TL;DR: Using gene expression signatures, an in silico strategy to map patterns of oncogenic pathway activation in 301 primary gastric cancers showed reproducible and significant survival differences in multiple cohorts, suggesting that pathway interactions may play an important role in influencing disease behavior.
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KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study (vol 108, pg 1495, 2013)
N.C.T. van Grieken,Toru Aoyama,Philip A. Chambers,Daniel Bottomley,Lindsay C. Ward,I. Inam,Tineke E. Buffart,Kakoli Das,T. Lim,Brendan Pang,Shen Li Zhang,Iain Beehuat Tan,Beatriz Carvalho,D.A.M. Heideman,Yohei Miyagi,Yoichi Kameda,Tomio Arai,Gerrit A. Meijer,Akira Tsuburaya,Puay Hoon Tan,Takaki Yoshikawa +20 more
TL;DR: The authors noted the misspelling of the name of the second author, T Aoyama, and the correct spelling is now displayed above.
8
The relationship between tumor cell density in the pretreatment biopsy and survival after chemotherapy in OE02 trial esophageal cancer patients.
Matthew D. Hale,Matthew Nankivell,Wolfram Mueller,Nicholas P. West,Sally P. Stenning,A Wright,Darren Treanor,Ruth E Langley,Lindsay C. Ward,William H. Allum,David Cunningham,Jeremy D. Hayden,Heike I. Grabsch +12 more
TL;DR: It is investigated whether tumour cell density (TCD) in the pre-chemo biopsy can predict patient benefit from chemo among OE02 patients and its predictive value (heterogeneity of treatment effect) was assessed.
5
KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study
N.C.T. van Grieken,T Aoyma,Philip A. Chambers,Daniel Bottomley,Lindsay C. Ward,I. Inam,Tineke E. Buffart,Kakoli Das,T. Lim,Brendan Pang,Shen Li Zhang,Iain Beehuat Tan,Beatriz Carvalho,D.A.M. Heideman,Yohei Miyagi,Yoichi Kameda,Tomio Arai,Gerrit A. Meijer,Akira Tsuburaya,Patrick Tan,Takaki Yoshikawa,Heike Grabsch +21 more
TL;DR: This large multicentre study demonstrated that KRAS mutations and DNA MMR deficiency have a role in a small sub group of GC irrespective of country of origin, suggesting that this subgroup of GC may have developed along a common pathway.