Linda Partridge
Max Planck Society
518 Papers
5.7K Citations
Linda Partridge is an academic researcher from Max Planck Society. The author has contributed to research in topics: Biology & Population. The author has an hindex of 118, co-authored 491 publications. Previous affiliations of Linda Partridge include University of York & University College London.
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Papers
The Ecological Context of Life History Evolution
Linda Partridge,Paul H. Harvey +1 more
TL;DR: There is now a good theoretical understanding of life history evolution, and detailed explicit optimality models have been constructed, but these present a challenge for empirical work examining some of the assumptions, such as the extent and mechanisms of the costs of growth and reproduction.
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
Shizuka B. Yamada,Tania F. Gendron,Teresa Niccoli,Teresa Niccoli,Naomi R. Genuth,Rosslyn Grosely,Yingxiao Shi,Idoia Glaria,Nicholas J. Kramer,Lisa Nakayama,Shirleen Fang,Tai J. I. Dinger,Annora Thoeng,Annora Thoeng,Gabriel Rocha,Maria Barna,Joseph D. Puglisi,Linda Partridge,Justin K. Ichida,Adrian M. Isaacs,Leonard Petrucelli,Aaron D. Gitler +21 more
TL;DR: A genetic screen for regulators of RAN translation is performed and small ribosomal protein subunit 25 (RPS25) is identified, presenting a potential therapeutic target for C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia and other neurodegenerative diseases caused by nucleotide repeat expansions.
Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix
Helena M. Cochemé,Caroline Quin,Stephen J. McQuaker,Filipe Cabreiro,Angela Logan,Tracy A. Prime,Irina Abakumova,Jigna V. Patel,Ian M. Fearnley,Andrew M. James,Carolyn M. Porteous,Robin A.J. Smith,Saima Saeed,Jane E. Carré,Mervyn Singer,David Gems,Richard C. Hartley,Linda Partridge,Michael P. Murphy +18 more
TL;DR: There was an increase in mitochondrial H2O2 with age in flies, which was not coordinately altered by interventions that modulated life span, and it is suggested that while a increase in overall mitochondrial H 2O2 correlates with aging, it may not be causative.
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation.
Li Li,Devon M Conradson,Vinita Bharat,Min Joo Kim,Chung-Han Hsieh,Paras S. Minhas,Amanda M. Papakyrikos,Aarooran Sivakumaran Durairaj,Anthony V. Ludlam,Katrin I. Andreasson,Linda Partridge,Linda Partridge,Michael A. Cianfrocco,Xinnan Wang +13 more
- 01 Sep 2021
TL;DR: In this paper, an inside-out redox signal of mitochondria was reported, and it was shown that blocking the MIC60-Miro interaction or reducing either protein, genetically or pharmacologically, extends lifespan and health-span of healthy fruit flies.
Effects of egg-production and of exposure to males on female survival in Drosophila melanogaster
TL;DR: F Females continuously exposed to males lived less long than intermittently exposed females, and this longevety difference could not be explained in terms of differences in either rate of egg-production or egg-hatchability.