Linda Partridge
Max Planck Society
518 Papers
5.7K Citations
Linda Partridge is an academic researcher from Max Planck Society. The author has contributed to research in topics: Biology & Population. The author has an hindex of 118, co-authored 491 publications. Previous affiliations of Linda Partridge include University of York & University College London.
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Papers
Gender and longevity: Why do men die earlier than women? Comparative and experimental evidence
TL;DR: It is suggested that the cross-regulation of steroid hormone and nutrient-sensing signalling pathways is a promising process for further study in understanding the biological basis for the gender gap.
Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster.
Hrvoje Augustin,Kieran McGourty,Marcus J. Allen,Jennifer Adcott,Chi Tung Wong,Emmanuel Boucrot,Linda Partridge,Linda Partridge +7 more
TL;DR: It is shown that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit, highlighting the relevance of the nervous system for aging.
Myostatin-like proteins regulate synaptic function and neuronal morphology.
Hrvoje Augustin,Hrvoje Augustin,Kieran McGourty,Joern R. Steinert,Helena M. Cochemé,Jennifer Adcott,Jennifer Adcott,Melissa Cabecinha,Alec J. Vincent,Els F. Halff,Josef T. Kittler,Emmanuel Boucrot,Linda Partridge,Linda Partridge +13 more
TL;DR: Myoglianin (MYO), the Drosophila homolog of myostatin and GDF11, regulates not only body weight and muscle size, but also inhibits neuromuscular synapse strength and composition in a Smad2-dependent manner, highlighting a key role for these proteins in synapse function and neuronal growth.
Mating and hormonal triggers regulate accessory gland gene expression in male Drosophila
TL;DR: By exposing males to females whose ovipositors had been sealed shut, it is shown that resynthesis of accessory gland proteins occurs only when seminal fluid is transferred to females, and applying juvenile hormone or 20-hydroxyecdysone topically to the cuticle of male flies showed that these hormones can act in vivo to stimulate the synthesis of accessory glands proteins to levels similar to those observed after mating.
Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry
Angela Logan,Victoria R. Pell,Karl J. Shaffer,Cameron Evans,Nathan J Stanley,Ellen L. Robb,Tracy A. Prime,Edward T. Chouchani,Helena M. Cochemé,Helena M. Cochemé,Ian M. Fearnley,Sara Vidoni,Andrew M. James,Carolyn M. Porteous,Linda Partridge,Thomas Krieg,Robin A.J. Smith,Michael P. Murphy +17 more
TL;DR: An approach that utilizes two mitochondria-targeted probes each containing a triphenylphosphonium lipophilic cation that drives their accumulation in response to Δψm and the plasma membrane potential is developed, enabling assessment of subtle changes in membrane potentials within cells and in the mouse heart in vivo.