Linda Partridge
Max Planck Society
518 Papers
5.7K Citations
Linda Partridge is an academic researcher from Max Planck Society. The author has contributed to research in topics: Biology & Population. The author has an hindex of 118, co-authored 491 publications. Previous affiliations of Linda Partridge include University of York & University College London.
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Papers
Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies
Linda Partridge,Hrvoje Augustin,Jennifer Adcott,Fiona Kerr,Alec J. Vincent,Emmanuel Boucrot +5 more
- 01 Sep 2017
TL;DR: Chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber system by increasing targeting of the gap junctional protein innexin shaking-B to gap junctions, pointing to a cellular mechanism for therapeutic intervention into aging-related neuronal disorders.
Ageing as a risk factor for ALS/FTD.
TL;DR: Some of the shared mechanisms between the ageing process itself and emerging pathogenic mechanisms in ALS/FTD are highlighted.
On Measuring the Rate of Ageing
TL;DR: It is proposed that Fisher’s ‘reproductive value’ is a natural measure of state at each age, which includes prospects for both survival and reproduction, and if this measure is used, the apparently anomalous findings are not at variance with evolutionary theories of ageing.
Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease
Oyinkan Sofola-Adesakin,Jorge Iván Castillo-Quan,Charalampos Rallis,Luke S Tain,Ivana Bjedov,Iain Rogers,Li Li,Pedro Martinez,Mobina Khericha,Melissa Cabecinha,Jurg Bahler,Linda Partridge +11 more
TL;DR: It is found that lithium caused a reduction in protein synthesis in Drosophila and hence the level of Aβ42, which highlights a role for lithium and reduced protein synthesis as potential therapeutic targets for AD pathogenesis.
Dynamics of the action of dFOXO on adult mortality in Drosophila.
Maria E. Giannakou,Martin Goss,Jake Jacobson,Giovanna Vinti,Sally J. Leevers,Linda Partridge +5 more
TL;DR: It is shown that in Drosophila continuous d FOXO overexpression in adult fat body reduces mortality rate throughout adulthood, and alteration of expression levels of dFOXO may have declining effects on IIS status with age, indicating that alteration of expressions of dfoxO may be declining, or that there could be some process that prevents or lessens the physiological response to a switch in IISstatus.