Linda Grosche
University of Erlangen-Nuremberg
8 Papers
27 Citations
Linda Grosche is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Immune system & Chemokine receptor. The author has an hindex of 7, co-authored 8 publications.
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Papers
The CD83 Molecule - An Important Immune Checkpoint.
Linda Grosche,Ilka Knippertz,Christina König,Dmytro Royzman,Andreas B. Wild,Elisabeth Zinser,Heinrich Sticht,Yves A. Muller,Alexander Steinkasserer,Matthias Lechmann +9 more
TL;DR: The regulatory functions of CD83 are reviewed, including its striking modulatory potential to maintain the balance between tolerance versus inflammation during homeostasis or pathologies, which emphasize its exceptional therapeutic potential.
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Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1.
Aykut Turan,Linda Grosche,Adalbert Krawczyk,Petra Mühl-Zürbes,Christina Drassner,Alexandra Düthorn,Mirko Kummer,Mike Hasenberg,Sylvia Voortmann,Holger Jastrow,Jan Dörrie,Niels Schaft,Max E. Kraner,Katinka Döhner,Beate Sodeik,Alexander Steinkasserer,Christiane Silke Heilingloh +16 more
TL;DR: It is hypothesized that inhibition of autophagic lamin degradation in mDCs represents a very powerful cellular counterstrike to inhibit the production of progeny virus and thus viral spread.
Herpes Simplex Virus Type 1 Propagation, Titration and Single-step Growth Curves
Linda Grosche,Katinka Döhner,Alexandra Düthorn,Ana Hickford-Martinez,Alexander Steinkasserer,Beate Sodeik +5 more
- 05 Dec 2019
TL;DR: Methods to prepare and characterize high-titer HSV-1 stocks with low genome to titer ratios that are required for infection studies in cell culture and animal experiments are described.
The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells
Christiane Silke Heilingloh,Linda Grosche,Mirko Kummer,Petra Mühl-Zürbes,Lisa Kamm,Myriam Scherer,Melanie Latzko,Thomas Stamminger,Alexander Steinkasserer +8 more
TL;DR: Results of infection kinetics and cycloheximide-actinomycin D-chase experiments strongly suggested that an HCMV immediate early gene product is responsible for the induction of CD83 down-modulation, and the major immediate early protein IE2 was identified as the viral effector protein that induces proteasomal CD83 degradation.
Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells
Linda Grosche,Petra Mühl-Zürbes,Barbara Ciblis,Adalbert Krawczyk,Christine Kuhnt,Lisa Kamm,Alexander Steinkasserer,Christiane Silke Heilingloh,Christiane Silke Heilingloh +8 more
TL;DR: It is hypothesized that hampering antigen delivery to secondary lymphoid organs by inhibition of mDC migration is an evolutionary conserved strategy among distinct members of Herpesviridae.
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