Linda Duque
University of Miami
9 Papers
25 Citations
Linda Duque is an academic researcher from University of Miami. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 6, co-authored 8 publications.
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Papers
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Eric M. Reiman,Joseph F. Arboleda-Velasquez,Yakeel T. Quiroz,Matthew J. Huentelman,Thomas G. Beach,Richard J. Caselli,Yinghua Chen,Yi Su,Amanda J. Myers,John Hardy,Jean Paul Vonsattel,Steven G. Younkin,David A. Bennett,Philip L. De Jager,Eric B. Larson,Paul K. Crane,C. Dirk Keene,M. Ilyas Kamboh,Julia Kofler,Linda Duque,John Gilbert,Harry E. Gwirtsman,Joseph D. Buxbaum,Dennis W. Dickson,Matthew P. Frosch,Bernardino Ghetti,Kathryn L. Lunetta,Li-San Wang,Bradley T. Hyman,Walter A. Kukull,Tatiana Foroud,Jonathan L. Haines,Richard Mayeux,Margaret A. Pericak-Vance,Julie A. Schneider,John Q. Trojanowski,Lindsay A. Farrer,Gerard D. Schellenberg,Gary W. Beecham,Thomas J. Montine,Gyungah Jun +40 more
TL;DR: The impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias.
Gary W. Beecham,Kara Hamilton,Adam C. Naj,Eden R. Martin,Matthew J. Huentelman,Amanda J. Myers,Jason J. Corneveaux,John Hardy,Jean Paul Vonsattel,Steven G. Younkin,David A. Bennett,Philip L. De Jager,Eric B. Larson,Paul K. Crane,M. Ilyas Kamboh,Julia Kofler,Deborah C. Mash,Linda Duque,John R. Gilbert,Harry E. Gwirtsman,Joseph D. Buxbaum,Patricia L. Kramer,Dennis W. Dickson,Lindsay A. Farrer,Matthew P. Frosch,Bernardino Ghetti,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Margaret A. Pericak-Vance,Julie A. Schneider,John Q. Trojanowski,Eric M. Reiman,Gerard D. Schellenberg,Thomas J. Montine +35 more
TL;DR: A genome-wide association study and analysis of known genetic risk loci for AD dementia using neuropathologic data from 4,914 brain autopsies discovered new genetic associations with specific neuro Pathologic features and aligned known geneticrisk for AD Alzheimer's disease with specific Neuropathologic changes in the largest brain autopsy study of AD and related dementias.
Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
Robert A. Moyer,Danxin Wang,Audrey C. Papp,Ryan M. Smith,Linda Duque,Deborah C. Mash,Wolfgang Sadee +6 more
TL;DR: The role of rs2283265/rs1076560 in D2 alternative splicing and its effects on reducing formation of D2S relative to D2L were confirmed and support a strong role in susceptibility to cocaine abuse.
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Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes.
TL;DR: It is reported here that ibogaine therapy administered in a safe dose range diminishes opioid withdrawal symptoms and reduces drug cravings and product development of single oral dose administration of Ibogaine for the treatment of opioid withdrawal during medically supervised detoxification to transition drug dependent individuals to abstinence is supported.
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Microglia activation in postmortem brains with schizophrenia demonstrates distinct morphological changes between brain regions.
Ryan Gober,Maryam Ardalan,Maryam Ardalan,Seyedeh Marziyeh Jabbari Shiadeh,Seyedeh Marziyeh Jabbari Shiadeh,Linda Duque,Susanna P. Garamszegi,Maureen C. Ascona,Ayled Barreda,Xiaoyan Sun,Carina Mallard,Regina Vontell +11 more
TL;DR: In this article, the authors used brain samples from sixteen donors with schizophrenia and thirteen control donors to assess the differential activation of microglia by quantifying density and 3D reconstruction.
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