Lina Wang
University of Wisconsin-Madison
20 Papers
11 Citations
Lina Wang is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 9, co-authored 14 publications. Previous affiliations of Lina Wang include University of California, San Diego & Ohio State University.
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Papers
α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling
TL;DR: A model in which α-syn multimers cluster synaptic vesicles, restricting their trafficking and recycling, and consequently attenuate neurotransmitter release is proposed, suggesting a novel role for these higher-order structures.
238
A dynamic formin-dependent deep F-actin network in axons
Archan Ganguly,Yong Tang,Lina Wang,Kelsey Ladt,Jonathan Loi,Bénédicte Dargent,Christophe Leterrier,Subhojit Roy +7 more
TL;DR: Low-light live imaging of F-actin–selective probes, quantitative tools, and super-resolution microscopy reveals a dynamic, formin-dependent deep F- actin cytoskeletal network in axons.
Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
Jichao Sun,Lina Wang,Huan Bao,Sanjay Premi,Utpal Das,Edwin R. Chapman,Edwin R. Chapman,Subhojit Roy +7 more
TL;DR: It is shown that α- synuclein–VAMP2 interactions are necessary for α-syn–induced synaptic attenuation, and this data connects divergent views and suggest a unified model ofα-syn function.
157
CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage
Jichao Sun,Jared Carlson-Stevermer,Utpal Das,Minjie Shen,Marion Delenclos,Amanda M. Snead,So Yeon Koo,Lina Wang,Dianhua Qiao,Jonathan Loi,Andrew J. Petersen,Michael E. Stockton,Anita Bhattacharyya,Mathew V. Jones,Xinyu Zhao,Pamela J. McLean,Andrew Sproul,Krishanu Saha,Subhojit Roy +18 more
TL;DR: A CRISPR/Cas9-based strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregulating neuroprotective α-cleavage is described.
A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport
Lina Wang,Anthony Brown +1 more
TL;DR: Investigating the effect of an SPG10 mutation in kinesin-1A on neurofilament transport in cultured mouse cortical neurons using live-cell fluorescent imaging reveals subtle complexities to the functional interdependence of the anterograde and retrograde neurofilaments.