Lin Zheng
Zhejiang University
13 Papers
51 Citations
Lin Zheng is an academic researcher from Zhejiang University. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 7, co-authored 9 publications.
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Papers
MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells
Ying Chen,Dandan Wang,Yeping Wu,Dan Su,Tianyi Zhou,Renhua Gai,Yingying Fu,Lin Zheng,Qiaojun He,Hong Zhu,Bo Yang +10 more
TL;DR: It is demonstrated that MDM2 functions as a key factor to drive EMT and motility of ovarian SKOV3 cells, by facilitating the activation of TGF-β-Smad pathway, which results in the increased transcription of snail/slug and the subsequent loss of E-cadherin levels.
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Chengsong Yan,Lin Zheng,Shutan Jiang,Haochen Yang,Jun Guo,Luyi Jiang,Tongzhou Li,Haosong Zhang,Yibing Bai,Yu Lou,Qi Zhang,Tingbo Liang,Wolfgang W. A. Schamel,Haopeng Wang,Weiwei Yang,Guangchuan Wang,Zheng-Jiang Zhu,Bao-Liang Song,Chenqi Xu +18 more
TL;DR: In this article , the authors analyzed the cholesterol atlas in the tumor microenvironment and found that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance.
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circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling
Lin Zheng,Hui Liang,Qiaoling Zhang,Z. Shen,Yixin Sun,Xuyang Zhao,Jingjing Gong,Zhiyuan Hou,Kewei Jiang,Quan Wang,Yan J. Jin,Yuxin P. Yin +11 more
TL;DR: In this article , a circular RNA generated from the PTEN gene, designated circPTEN1, that is frequently downregulated in colorectal cancer, and decreased expression of PTEN1 predicts poor survival was identified.
Simultaneous NF‐κB inhibition and E‐cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo
Lin Zheng,Yingying Fu,Lin-han Zhuang,Renhua Gai,Jian Ma,Jianshu Lou,Hong Zhu,Qiaojun He,Bo Yang +8 more
TL;DR: It is demonstrated that the combination of celastrol and SAHA exerted substantial synergistic efficacy against human cancer cells in vitro and in vivo accompanied by enhanced caspase‐mediated apoptosis, and was superior to other combination regimens that rely on a single mechanism.
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GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1
Lin Zheng,Wei Yang,Chong Zhang,Wanjing Ding,Hong Zhu,Nengming Lin,Honghai Wu,Qiaojun He,Bo Yang +8 more
TL;DR: The present study showed that GDC-0941 potently sensitized breast cancer to ABT-737 in vitro and in vivo and exerted increased anti-tumor efficacy on MDA-MB-231 xenograft models.
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