Lin Zheng
5 Papers
Lin Zheng is an academic researcher. The author has contributed to research in topics: Leukemia & Myeloid leukemia. The author has an hindex of 1, co-authored 2 publications.
Chat about Author
Papers
Low TYROBP expression predicts poor prognosis in multiple myeloma
Hong Luo,Chengyun Pan,Li Wang,Lin Zheng,Shuyun Cao,Xiuying Hu,Tianzhen Hu,Naiqin Zhao,Qin Shang,Jishi Wang +9 more
TL;DR: This study identifies TYROBP as a potential prognostic marker for multiple myeloma, with low expression predicting poor prognosis, and demonstrates its role in cell adhesion and migration, suggesting a novel therapeutic target for this refractory hematologic cancer.
4
Nrf2 Overexpression Increases Risk of Venetoclax Resistance in Acute Myeloid Leukemia By Promoting Glycolysis
TL;DR: In this paper , the authors investigated the mechanism by which NRF2 mediated venetoclax-resistance of acute myeloid leukemia (AML) through promoting the metabolic homeostasis.
3
Overexpression of Nrf2 in Mesenchymal Stem Cells Promotes Migration and Invasion of B- Acute Lymphoblastic Leukemia Cells
Lin Zheng,Chengyun Pan,Qin Shang,Tianzhen Hu,Shuyun Cao,Li Wang,Hong Luo,Weili Wang,Jishi Wang +8 more
TL;DR: The overexpression of Nrf2 in MSCs promotes the migration and invasion of leukemic cells by activating the activity of SDF-1-CXCR4 axis and regulates the expression of genes encoding antioxidant enzymes to prevent various oxidative changes.
Exosomal miR-196a-5p Secreted by Bone Marrow Mesenchymal Stem Cells Inhibits Ferroptosis and Promotes Drug Resistance of Acute Myeloid Leukemia.
Bingjie Fan,Li Wang,Tianzhen Hu,Lin Zheng,Jishi Wang +4 more
TL;DR: Exosomes secreted by bone marrow mesenchymal stem cells inhibit ferroptosis and promote drug resistance in acute myeloid leukemia by increasing miR-196a-5p expression, which reduces lipid ROS and ferroptosis through NEDD4L-mediated ubiquitination inhibition of ACSL3.
Nuclear factor Nrf2 promotes glycosidase OGG1 expression by activating the AKT pathway to enhance leukemia cell resistance to cytarabine
Qin Shang,Chengyun Pan,Xi Zhang,Tonghua Yang,Tianzhen Hu,Lin Zheng,Shuyun Cao,C. Feng,Xiuying Hu,Xiao Chai,Ji-Shi Wang,Qin Fang +11 more
TL;DR: Wang et al. as mentioned in this paper found that upregulation of nuclear factor E2-related factor 2 (Nrf2) in leukemia cells by lentivirus transfection could decrease the sensitivity of leukemia cells to cytarabine and decrease OGG1 expression.