Lin Yuan
Shandong University
13 Papers
Lin Yuan is an academic researcher from Shandong University. The author has contributed to research in topics: Neuroprotection & Microglia. The author has an hindex of 8, co-authored 10 publications.
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Papers
Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice
Lin Yuan,Song Liu,Xuemei Bai,Yan Gao,Guangheng Liu,Xueer Wang,Dexiang Liu,Tong Li,Aijun Hao,Zhen Wang +9 more
TL;DR: It is demonstrated that OT possesses anti-neuroinflammatory activity and might serve as a potential therapeutic agent for treating neuroinflammatory diseases.
The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration
TL;DR: It is demonstrated that curcumin may be an effective therapeutic agent for LPS-induced depressive-like behavior, partially due to its anti-inflammatory aptitude.
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Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation.
Qun Zhang,Lin Yuan,Dexiang Liu,Jianmei Wang,Shuanglian Wang,Qingrui Zhang,Yanfen Gong,Hongda Liu,Aijun Hao,Zhen Wang +9 more
TL;DR: H2S exerts neuroprotection against hypoxia-induced neurotoxicity through its anti-inflammatory effect in microglia through inhibition of iNOS, NF-κB, ERK and p38 MAPK signaling pathways, suggesting a potential therapeutic application of H2S releasing drugs in hypoxic brain damage treatment.
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Mesenchymal stem cell-derived extracellular vesicles promote microglial M2 polarization after subarachnoid hemorrhage in rats and involve the AMPK/NF-κB signaling pathway.
Min Han,Ying Cao,Xiaofan Guo,Xili Chu,Tingting Li,Hao Xue,Danqing Xin,Lin Yuan,Hongfei Ke,Gang Li,Zhen Wang +10 more
TL;DR: Investigation of the effects of MSCs-EVs on neuroinflammation and the polarization regulation of microglia to the M2 phenotype and related signaling pathways after SAH in rats found their use as a potential treatment strategy for early SAH may be supported.
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Neuroprotective Effects of Hydrogen Sulfide Against Early Brain Injury and Secondary Cognitive Deficits Following Subarachnoid Hemorrhage
Tong Li,Hansen Liu,Hao Xue,Jinsen Zhang,Xiao Han,Shaofeng Yan,Shishi Bo,Song Liu,Lin Yuan,Lin Deng,Gang Li,Zhen Wang +11 more
TL;DR: It is demonstrated that NaHS, as an exogenous H2S donor, could significantly alleviate the development of EBI and cognitive dysfunction induced by SAH via Akt/ERK‐related antiapoptosis pathway, and upregulating BDNF‐CREB expression.
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