Lin Wei
Chongqing Medical University
6 Papers
29 Citations
Lin Wei is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Genotype & Single-nucleotide polymorphism. The author has an hindex of 6, co-authored 6 publications.
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Papers
A functional variant of pre-miRNA-196a2 confers risk for Behcet’s disease but not for Vogt–Koyanagi–Harada syndrome or AAU in ankylosing spondylitis
Jian Qi,Shengping Hou,Qi Zhang,Dan Liao,Lin Wei,Jing Fang,Yan Zhou,Aize Kijlstra,Peizeng Yang +8 more
TL;DR: It is shown that a functional variant of miR-196a2 confers risk for Behcet’s disease but not for VKH syndrome or AAU+AS+ by modulating the miR -196a gene expression and by regulating pro-inflammatory IL-1β and MCP-1 production.
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MicroRNA-146a and Ets-1 gene polymorphisms are associated with pediatric uveitis.
Lin Wei,Qingyun Zhou,Shengping Hou,Lin Bai,Yunjia Liu,Jian Qi,Qin Xiang,Yan Zhou,Aize Kijlstra,Peizeng Yang +9 more
TL;DR: It is shown that miR-146a and Ets-1 are both associated with pediatric uveitis in Han Chinese and SNP rs10893872 may affect the genetic predisposition to pediatric Uveitis by modulating expression of ETS-1.
AAV2-mediated subretinal gene transfer of mIL-27p28 attenuates experimental autoimmune uveoretinitis in mice.
Lichun Tian,Peizeng Yang,Bo Lei,Ju Shao,Chaokui Wang,Qin Xiang,Lin Wei,Zhougui Peng,Aize Kijlstra +8 more
TL;DR: Subretinal injection of the AAV2-murine IL-27p28 vector significantly attenuated the severity of EAU disease clinically and pathologically in association with a significantly decreased IL-17 expression and an increased IL-10 expression.
AAV2-mediated combined subretinal delivery of IFN-α and IL-4 reduces the severity of experimental autoimmune uveoretinitis.
TL;DR: There was no difference concerning DTH (delayed-type hypersensitivity) reaction, lymphocyte proliferation and IL-17 production among the investigated treatment groups, suggesting that local retinal gene delivery did not affect the systemic immune response.
MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behçet's disease and Vogt–Koyanagi–Harada syndrome
Qingyun Zhou,Shengping Hou,Liang Liang,Xinyu Li,Xiaoyu Tan,Lin Wei,Bo Lei,Aize Kijlstra,Peizeng Yang +8 more
TL;DR: A strong association of rs2910164 of miR-146a with BD with a significantly decreased frequency of the homozygous rs29 10164 CC genotype and C allele was observed in patients with BD compared with controls and decreased expression ofmiR- 146a and certain proinflammatory cytokines in individuals carrying the CC genotypes was identified.