11 Papers
8 Citations
Lin Wang is an academic researcher from Shandong University of Traditional Chinese Medicine. The author has contributed to research in topics: Influenza A virus & Virus. The author has an hindex of 4, co-authored 7 publications.
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Papers
Identification of Chebulinic Acid and Chebulagic Acid as Novel Influenza Viral Neuraminidase Inhibitors.
Ping Li,Ruikun Du,Yanyan Wang,Xuewen Hou,Lin Wang,Xiujuan Zhao,Peng Zhan,Xinyong Liu,Lijun Rong,Qinghua Cui +9 more
TL;DR: CHLA and CHLI are promising new NA inhibitors that may be further developed as novel antiviral therapies against IAVs.
Punicalagin is a neuraminidase inhibitor of influenza viruses.
Ping Li,Ruikun Du,Zinuo Chen,Yanyan Wang,Peng Zhan,Xinyong Liu,Dongwei Kang,Zhaoyu Chen,Xiujuan Zhao,Lin Wang,Lijun Rong,Qinghua Cui +11 more
TL;DR: Punicalagin from plants possesses strong anti‐influenza activity with a low micromolar IC50 value in tissue culture, and can inhibit replication of different strains of influenza A and B viruses, including oseltamivir‐resistant virus, indicating that punicalagin is a broad spectrum antiviral against both IAV and IBV.
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A Mechanism Underlying Attenuation of Recombinant Influenza A Viruses Carrying Reporter Genes.
Xiujuan Zhao,Lin Wang,Qinghua Cui,Ping Li,Yanyan Wang,Yingying Zhang,Yong Yang,Lijun Rong,Ruikun Du +8 more
TL;DR: A mechanism underlying attenuation of reporter IAVs is unraveled, which suggests a new approach to restore infectivity and virulence by introducing extra mutations compensating for the impaired replication property of corresponding segments.
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A Parallel Phenotypic Versus Target-Based Screening Strategy for RNA-Dependent RNA Polymerase Inhibitors of the Influenza A Virus
TL;DR: A phenotypic versus target-based screening strategy was established to identify the influenza A virus inhibitors targeting the virus RNA transcription/replication steps by sequentially using an RdRp-targeted screen and a replication-competent reporter virus-based approach using the same compounds.
Exploration of the mechanism by which Huangqi Guizhi Wuwu decoction inhibits Lps-induced inflammation by regulating macrophage polarization based on network pharmacology
Sutong Wang,Tianshu Ji,Lin Wang,Yi Qu,Xinhui Wang,Wen‐ting Wang,Mujie Lv,Yongcheng Wang,Xiao Li,Ping Jiang +9 more
TL;DR: Huangqi Guizhi Wuwu decoction (HQGZWWD) is a traditional Chinese herbal medicine formulation with significant anti-inflammatory activity as discussed by the authors , but its underlying mechanism remains unknown.