4 Papers
24 Citations
Lin Wang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Notch signaling pathway & Regulation of gene expression. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Lin Wang include Union Hospital.
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Papers
Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans.
Laura C. Kelley,Zheng Wang,Zheng Wang,Elliott J. Hagedorn,Lin Wang,Wanqing Shen,Shijun Lei,Sam A. Johnson,David R. Sherwood +8 more
TL;DR: This protocol describes multichannel time-lapse confocal imaging of anchor-cell invasion in live Caenorhabditis elegans and can be combined with genetic analysis, molecular-activity probes and optogenetic approaches to uncover the molecular mechanisms underlying cell invasion.
Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling
Shelly Th McClatchey,Zheng Wang,Lara M. Linden,Eric Hastie,Lin Wang,Lin Wang,Wanqing Shen,Wanqing Shen,Alan Chen,Qiuyi Chi,David R. Sherwood +10 more
TL;DR: A new morphogenetic signaling pathway is revealed that controls BM sliding to remodel tissues and restricts BM adhesion receptor DGN-1 (dystroglycan) trafficking to the cell-BM interface, which promotes BM sliding.
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MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans
TL;DR: It is reported that MIG-10 synergizes with UNC-6 to promote AC attachment to the BM, revealing a functional role for Mig-10 in stabilizing AC-BM adhesion and suggesting the functional importance of the negative regulation on mig-10 expression.
12
Combined blockade of Tim-3 and MEK inhibitor enhances the efficacy against melanoma.
Yang Liu,Pengcheng Cai,Ning Wang,Qianwen Zhang,Fenghua Chen,Liang Shi,Yang Zhang,Lin Wang,Li-Hua Hu +8 more
TL;DR: This study reported the combination of trametinib and anti-Tim-3 monoclonal antibody (mAb) in treating B16-F10 melanoma mice and discovered that tramet inib remarkably promoted apoptosis and inhibited cell proliferation while inhibition of MEK improved the expression of Tim-3 and caused the decrease of CD8+ T cells.