Lin Wang
Wuhan University
21 Papers
23 Citations
Lin Wang is an academic researcher from Wuhan University. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Blood–brain barrier. The author has an hindex of 8, co-authored 18 publications. Previous affiliations of Lin Wang include University of Southern California & Chinese Ministry of Education.
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Papers
Circulating Brain Microvascular Endothelial Cells (cBMECs) as Potential Biomarkers of the Blood–Brain Barrier Disorders Caused by Microbial and Non-Microbial Factors
Sheng-He Huang,Sheng-He Huang,Lin Wang,Lin Wang,Feng Chi,Chun-Hua Wu,Hong Cao,Aimin Zhang,Ambrose Jong +8 more
TL;DR: Results demonstrated that cBMECs as well as EPCs may be used as potential cell-based biomarkers for indexing of BBB injury and plays an important role in CNS inflammation and BBB disorders caused by microbial and non-microbial factors.
Meningitic Escherichia coli K1 Penetration and Neutrophil Transmigration Across the Blood–Brain Barrier are Modulated by Alpha7 Nicotinic Receptor
Feng Chi,Lin Wang,Lin Wang,Xueye Zheng,Chun-Hua Wu,Ambrose Jong,Michael A. Sheard,Wei Shi,Sheng-He Huang +8 more
TL;DR: The data suggest that α7 nAChR plays a detrimental role in the host defense against meningitic infection by modulation of pathogen invasion, PMN recruitment, calcium signaling and neuronal inflammation.
Recruitment of α7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells.
TL;DR: In this article, the α7 nicotinic acetylcholine receptor (α7 nAChR) contributes to the nicotine-enhanced Escherichia coli K1 invasion of human brain microvascular endothelial cells (HBMECs) through lipid rafts/caveolae-mediated signaling.
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Nicotine Reduces Human Brain Microvascular Endothelial Cell Response to Escherichia coli K1 Infection by Inhibiting Autophagy.
Chao Wu,Mengzhen Yang,Rui Liu,Rui Liu,Hanyang Hu,Lulu Ji,Xiaoli Zhang,Sheng-He Huang,Sheng-He Huang,Lin Wang +9 more
TL;DR: It is concluded that nicotine could inhibit HBMEC autophagy upon E. coli K1 infection and decrease the scavenging effect on E.coli K1, thus promoting the occurrence and development of neonatal meningitis.
CD48 and α7 Nicotinic Acetylcholine Receptor Synergistically Regulate FimH-Mediated Escherichia coli K1 Penetration and Neutrophil Transmigration Across Human Brain Microvascular Endothelial Cells
Rui Liu,Rui Liu,Chao Wu,Li Li,Li Li,Feng Chi,Tiesong Zhang,Yating Xu,Lulu Ji,Zhiguo Chen,Hanyang Hu,Xiaoli Zhang,Sheng-He Huang,Sheng-He Huang,Lin Wang +14 more
TL;DR: FimH-induced E coli K1 invasion and PMN migration across HBMECs may be mediated by the CD48-α7nAChR complex in lipid rafts of H BMEC via Ca2+ signaling and cofilin dephosphorylation.