3 Papers
4 Citations
Lin Su is an academic researcher from Northeast Forestry University. The author has contributed to research in topics: Camptothecin & Triple quadrupole mass spectrometer. The author has an hindex of 3, co-authored 3 publications.
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Papers
Cytotoxicity and topo I targeting activity of substituted 10--nitrogenous heterocyclic aromatic group derivatives of SN-38.
TL;DR: Ethyl in the 7-position of these compounds can increase the cytotoxicity and inhibitory activity to topo I compared with corresponding pyridine salts CPT derivatives and simultaneously maintain good water solubility, consistent with the SAR of CPT.
15
Quantification of CPT13 in rat plasma using LC-MS/MS for a pharmacokinetic study.
Qing Yong Li,Lin Su,Yuan Gang Zu,Lin Zhang,Yang Gao,Chun Cheng Wang,Qiaochu Zhu,Xiao Qiu Deng +7 more
TL;DR: CPT13 in rat plasma was stable when stored at -20 °C or 4 °C for three freeze-thaw cycles, and the method was employed for the first time during pharmacokinetic studies of CPT 13 in rats following a single intravenous dose and three different oral doses.
4
Synthesis and antitumor activity of novel 20s-camptothecin analogues.
TL;DR: The results suggested that introduction of pyrazole in 10- or 20-position of camptothecin could promote antitumor activity in vitro and in vivo, simultaneously bring much increase of the stability of lactone.