Lin Shan
Chinese Academy of Sciences
8 Papers
Lin Shan is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Nucleolus & RNA. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Screening for functional circular RNAs using the CRISPR-Cas13 system.
Siqi Li,Xiang Li,Wei Xue,Lin Zhang,Liang-Zhong Yang,Shi-Meng Cao,Yun-Ni Lei,Yun-Ni Lei,Chu-Xiao Liu,Si-Kun Guo,Lin Shan,Man Wu,Xiao Tao,Jia-Lin Zhang,Xiang Gao,Xiang Gao,Jun Zhang,Jia Wei,Jinsong Li,Jinsong Li,Li Yang,Li Yang,Ling-Ling Chen,Ling-Ling Chen +23 more
TL;DR: A CRISPR–Cas13 system to effectively target circRNAs and screen their functions in vitro and in vivo is described, which enables the study of relevant circRNA phenotypes in human cell proliferation and in mouse embryogenesis.
298
Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells.
Chun-Jie Guo,Xu-Kai Ma,Yu-Hang Xing,Chuan-Chuan Zheng,Yi-Feng Xu,Lin Shan,Jun Zhang,Shaohua Wang,Yangming Wang,Gordon G. Carmichael,Li Yang,Li Yang,Ling-Ling Chen,Ling-Ling Chen +13 more
TL;DR: In this paper, the authors reported differing subcellular localization of lncRNAs in human and mouse embryonic stem cells (ESCs) and showed that a significantly higher fraction of lnRNAs is localized in the cytoplasm of hESCs than in mESCs.
271
Nascent Pre-rRNA Sorting via Phase Separation Drives the Assembly of Dense Fibrillar Components in the Human Nucleolus
Run-Wen Yao,Guang Xu,Ying Wang,Lin Shan,Peng-Fei Luan,Yang Wang,Man Wu,Liang-Zhong Yang,Yu-Hang Xing,Li Yang,Li Yang,Ling-Ling Chen,Ling-Ling Chen +12 more
TL;DR: The results unveil FC/DFC ultrastructures in nucleoli and suggest a conceptual framework for considering nascent RNA sorting using multivalent interactions of their binding proteins.
267
lncRNA SLERT controls phase separation of FC/DFCs to facilitate Pol I transcription.
Man Wu,Guang Xu,Chong Han,Peng-Fei Luan,Yu-Hang Xing,Fang Nan,Liang-Zhong Yang,Youkui Huang,Zheng-Hu Yang,Zheng-Hu Yang,Lin Shan,Li Yang,Li Yang,Jiaquan Liu,Ling-Ling Chen,Ling-Ling Chen +15 more
TL;DR: In this paper, the authors reported that individual spherical FC/DFC units are coated by the DEAD-box RNA helicase DDX21 in human cells, which suggests that SLERT is an RNA regulator that controls the biophysical properties of FC and DFCs.
119
Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance
Lin Shan,Guang Xu,Run-Wen Yao,Peng Luan,Youkui Huang,Peipei Zhang,Lin Zhang,Xiang Gao,Ying Li,Shi-Meng Cao,Shuai-Xin Gao,Zheng-Hu Yang,Siqi Li,Liang-Zhong Yang,Ying Wang,Catharine C L Wong,Li Yu,Jinsong Li,Li Yang,Ling-Ling Chen +19 more
TL;DR: Insight is provided into functional sub-nucleolar organization and a physiologically essential step in rRNA maturation that requires the static protein URB1 in the phase-separated nucleolus is identified.
50