Lin Ruan
Nanyang Technological University
7 Papers
Lin Ruan is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Chemistry & Antibiotics. The author has an hindex of 5, co-authored 7 publications.
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Papers
Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters
Kaixi Zhang,Yu Du,Yu Du,Zhangyong Si,Yang Liu,Michelle E. Turvey,Cheerlavancha Raju,Damien Keogh,Lin Ruan,Subramanion L. Jothy,Sheethal Reghu,Kalisvar Marimuthu,Partha Pratim De,Oon Tek Ng,Oon Tek Ng,José R. Mediavilla,Barry N. Kreiswirth,Yonggui Robin Chi,Jinghua Ren,Kam Chiu Tam,Xue-Wei Liu,Hongwei Duan,Yabin Zhu,Yuguang Mu,Paula T. Hammond,Guillermo C. Bazan,Kevin Pethe,Mary B. Chan-Park +27 more
TL;DR: An enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses biofilms and displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope.
A Glycosylated Cationic Block Poly(β-peptide) Reverses Intrinsic Antibiotic Resistance in All ESKAPE Gram-Negative Bacteria.
Zhangyong Si,Hui Wen Lim,Moon Y. F. Tay,Yu Du,Lin Ruan,Haofeng Qiu,Rubí Zamudio-Vázquez,Sheethal Reghu,Yahua Chen,Wen Shuo Tiong,Kalisvar Marimuthu,Kalisvar Marimuthu,Partha Pratim De,Oon Tek Ng,Oon Tek Ng,Yabin Zhu,Yunn-Hwen Gan,Yonggui Robin Chi,Hongwei Duan,Guillermo C. Bazan,Guillermo C. Bazan,E. Peter Greenberg,E. Peter Greenberg,Mary B. Chan-Park,Kevin Pethe +24 more
TL;DR: A cationic block beta-peptide (PAS8- b -PDM12) is reported that reverses intrinsic antibiotic resistances in GNB by two distinct mechanisms of action, indicating that it is technically possible for a single adjuvant to reverse innate antibiotic resistance in all pathogenic GNB of the ESKAPE group, including those resistant to last resort antibiotics.
Designer broad-spectrum polyimidazolium antibiotics
Wenbin Zhong,Zhenyu Shi,Surendra H. Mahadevegowda,Bo Liu,Kaixi Zhang,Chong Hui Koh,Lin Ruan,Yahua Chen,Merve S. Zeden,Carmen J. E. Pee,Kalisvar Marimuthu,Partha Pratim De,Oon Tek Ng,Oon Tek Ng,Yabin Zhu,Yonggui Robin Chi,Paula T. Hammond,Liang Yang,Liang Yang,Yunn-Hwen Gan,Kevin Pethe,E. Peter Greenberg,Angelika Gründling,Mary B. Chan-Park +23 more
TL;DR: The evidence indicates the Cationic peptide mimics, main-chain cationic polyimidazoliums (PIMs), have potential as candidates for development of new drugs for treatment of pan-resistant bacterial infections and PIM1, a particularly potent PIM, for mechanistic studies.
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Gram-Typing Using Conjugated Oligoelectrolytes
Cheng Zhou,Cheng Zhou,James C. S. Ho,Geraldine W. N. Chia,Alex S. Moreland,Lin Ruan,Bo Liedberg,Staffan Kjelleberg,Jamie Hinks,Guillermo C. Bazan +9 more
TL;DR: It is shown that COE‐S6 can be used as a fluorescent membrane probe that distinguishes between Gram‐negative and Gram‐positive bacteria in a single step, making it a promising membrane‐specific fluorescent probe.
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Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes.
TL;DR: Two membrane-intercalating conjugated oligoelectrolytes (COEs) were combined to achieve enhanced antimicrobial efficacy and biophysical experiments using liposome models suggest that COE-S6 promotes the interactions betweenCOE-D8 and lipid bilayers, in agreement with damages of cellular permeability and morphology.