Lin-Lin Xu
Chinese Academy of Sciences
7 Papers
37 Citations
Lin-Lin Xu is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virus & Viral replication. The author has an hindex of 5, co-authored 7 publications.
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Papers
Development of Neutralization Assay Using an eGFP Chikungunya Virus.
Cheng-Lin Deng,Si-Qing Liu,Dong-Gen Zhou,Lin-Lin Xu,Xiao-Dan Li,Pan-Tao Zhang,Peng-Hui Li,Han-Qing Ye,Hong-Ping Wei,Zhiming Yuan,Cheng-Feng Qin,Bo Zhang +11 more
TL;DR: A novel and reliable eGFP-CHIKV reporter virus-based neutralization assay that could be used for rapid screening neutralizing antibodies against CHIKV is developed.
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Development of a stable Gaussia luciferase enterovirus 71 reporter virus.
Lin-Lin Xu,Chao Shan,Cheng Lin Deng,Xiao-Dan Li,Bao Di Shang,Han-Qing Ye,Si Qing Liu,Zhiming Yuan,Qing Yin Wang,Pei Yong Shi,Bo Zhang +10 more
TL;DR: The reporter virus efficiently infects and replicates in various cell types (Vero, human rhabdomyosarcoma, and HeLa cells), producing robust luciferase activity and could be useful for antiviral drug discovery as well as for studying EV71 replication and pathogenesis.
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Visualization of chikungunya virus infection in vitro and in vivo.
Hong Lei Zhang,Hong Lei Zhang,Hao Long Dong,Ya-Nan Zhang,Lin-Lin Xu,Cheng Lin Deng,Xiao Feng Li,Xiao Feng Li,Xiao-Dan Li,Han-Qing Ye,Zhiming Yuan,Cheng-Feng Qin,Cheng-Feng Qin,Bo Zhang,Bo Zhang +14 more
TL;DR: A novel, replication-competent, CHIKV reporter virus encoding a near infrared fluorescent protein (iRFP) provides a powerful tool to track real time Chikungunya virus replication and to test the in vivo efficacy of vaccines and antiviral therapeutics.
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Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone
TL;DR: In this article, a stable infectious cDNA clone of an epidemic strain of Coxsackievirus A16 (CA16) was assembled, and subsequently a reporter virus (eGFP-CA16), was constructed by inserting the eGFP gene between the 5′-UTR and the N-terminus of VP4, with the addition of a 2A protease cleavage site (ITTLG) at its Cterminus.
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Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase
Chao Shan,Xiao-Dan Li,Cheng-Lin Deng,Baodi Shang,Lin-Lin Xu,Han-Qing Ye,Zhiming Yuan,Bo Zhang +7 more
TL;DR: A Gaussia luciferase (Gluc) reporter replicon of West Nile virus (WNV) and used it to quantify viral translation and RNA replication and will be useful for research in antiviral drug development programs, as well as for studying viral replication and pathogenesis of WNV.
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