Lin Lin
University at Buffalo
5 Papers
Lin Lin is an academic researcher from University at Buffalo. The author has contributed to research in topics: Histone methyltransferase & Histone methylation. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease.
Yan Zheng,Yan Zheng,Aiyi Liu,Aiyi Liu,Zi-Jun Wang,Qing Cao,Wei Wang,Lin Lin,Kaijie Ma,Freddy Zhang,Jing Wei,Emmanuel Matas,Jia Cheng,Guojun Chen,Xiaomin Wang,Zhen Yan +15 more
TL;DR: The results suggest that disrupted epigenetic regulation of glutamate receptor transcription underlies the synaptic and cognitive deficits in Alzheimer's disease, and targeting histone methylation enzymes may represent a novel therapeutic strategy for this prevalent neurodegenerative disorder.
142
Parkin Maintains Robust Pacemaking in Human Induced Pluripotent Stem Cell-Derived A9 Dopaminergic Neurons.
TL;DR: In this paper , the causal relationship between parkin mutations and the dysfunction of human A9 DA neurons was established using TALEN (transcription activator-like effector nuclease)- or CRISPR/Cas9-mediated gene targeting.
1
Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer’s Disease
TL;DR: It is found that glutamate receptor surface expression and synaptic function in frontal cortical neurons were significant diminished in a familial AD model, which was correlated with the reduction of phosphorylated cofilin, a key protein regulating the dynamics of actin filaments.
Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3 -deficient mice
Zi-Jun Wang,Ping Zhong,Kaijie Ma,Seo Js,Fengwei Yang,Zihua Hu,Freddy Zhang,Lin Lin,Jie Wang,Tao Liu,Emmanuel Matas,Paul Greengard,Zhen Yan +12 more
TL;DR: The results suggest that targeting histone methylation enzymes to adjust gene expression and ameliorate synaptic defects could be a potential therapeutic strategy for autism.
Inhibition of Histone Methyltransferases EHMT1/2 Reverses Amyloid-β-Induced Loss of AMPAR Currents in Human Stem Cell-Derived Cortical Neurons.
TL;DR: Results suggest that inhibition of the aberrant histone methylation is a novel approach to reverse Aβ-induced synaptic deficits in human neurons.