5 Papers
3 Citations
Lin Li is an academic researcher from Southern Medical University. The author has contributed to research in topics: DNA methylation & Chromatin. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Lin Li include Peking University.
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Papers
Integrated transcriptomics and epigenomics reveal chamber-specific and species-specific characteristics of human and mouse hearts.
Junpeng Gao,Yuxuan Zheng,Yuxuan Zheng,Lin Li,Minjie Lu,Xiangjian Chen,Yu Wang,Yanna Li,Xiaomeng Liu,Yun Gao,Yun Gao,Y. J. Mao,Y. J. Mao,Peng Zhao,Jinan Zhang,Fuchou Tang,Fuchou Tang,Lei Song,Lu Wen,Lu Wen,Jizheng Wang +20 more
TL;DR: This study applied nucleosome occupancy and methylome sequencing, which detected DNA methylation and chromatin accessibility simultaneously, as well as RNA-seq, for multiomics analysis of the 4 chambers of adult and fetal human hearts, and adult mouse hearts, showing conserved region-specific patterns in the mammalian heart.
5-Formylcytosine landscapes of human preimplantation embryos at single-cell resolution.
Yun Gao,Lin Li,Peng Yuan,Peng Yuan,Fan Zhai,Fan Zhai,Yixin Ren,Yixin Ren,Liying Yan,Liying Yan,Rong Li,Rong Li,Ying Lian,Ying Lian,Xiaohui Zhu,Xiaohui Zhu,Xinglong Wu,Kehkooi Kee,Lu Wen,Jie Qiao,Fuchou Tang +20 more
TL;DR: It is found that 5-formylcytosine phosphate guanine (5fCpG) exhibits genomic element-specific distribution features and is enriched in L1 and endogenous retrovirus-K (ERVK), the subfamilies of repeat elements long interspersed nuclear elements (LINEs) and long terminal repeats (LTRs), respectively.
Single-Cell Multi-omics Sequencing of Human Early Embryos
Lin Li,Fan Guo,Yun Gao,Yixin Ren,Peng Yuan,Liying Yan,Rong Li,Ying Lian,Jingyun Li,Boqiang Hu,Junpeng Gao,Lu Wen,Fuchou Tang,Jie Qiao +13 more
TL;DR: DNA demethylation and chromatin remodeling were unsynchronized in different genomic regions and the genomic regions showing the strongest variations in chromatin accessibility were enriched at the proximal and distal nucleosome-depleted regions and pluripotency master transcription factor–binding regions.
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Single-cell multi-omics sequencing of human early embryos
Lin Li,Fan Guo,Yun Gao,Yixin Ren,Yixin Ren,Peng Yuan,Peng Yuan,Liying Yan,Liying Yan,Rong Li,Rong Li,Ying Lian,Ying Lian,Jingyun Li,Boqiang Hu,Junpeng Gao,Lu Wen,Fuchou Tang,Jie Qiao +18 more
TL;DR: This work applies single-cell chromatin overall omic-scale landscape sequencing (scCOOL-seq) to generate a genome-wide map of DNA methylation and chromatin accessibility at single- cell resolution during human preimplantation development, paving the way for dissecting the complex, yet highly coordinated, epigenetic reprogramming duringhuman preim implantation development.
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution.
Li Li,Lin Li,Qingqing Li,Qingqing Li,Xixi Liu,Xinyi Ma,Jun Yong,Shuai Gao,Xinglong Wu,Yuan Wei,Xiaoye Wang,Wei Wang,Rong Li,Jie Yan,Xiaohui Zhu,Lu Wen,Lu Wen,Jie Qiao,Liying Yan,Liying Yan,Fuchou Tang,Fuchou Tang +21 more
TL;DR: The genome-wide DNA methylation and chromatin accessibility of human FGCs at different phases as well as gonadal niche cells at single-cell resolution are profiled and valuable insights are provided for understanding the strongly heterogeneous, unsynchronized, yet highly robust nature of human germ cell development.