Primary pulmonary hepatoid adenocarcinoma: A case report and review of the literature.

IntroductionHepatoid adenocarcinoma of the lung is an extremely rare type of the non-small cell lung cancer. Treatment principles and prognosis are similar to that of lung adenocarcinoma.Case repor...

Hepatoid adenocarcinoma of the lung and the review of the literature.

Hepatoid adenocarcinoma (HAC) is a rare and aggressive tumor characterized by histological similarities to hepatocellular carcinoma (HCC). While the stomach is the most common primary site for HAC, the tumor has also been reported to originate from other organs such as the gallbladder, pancreas, lung, ovary, bladder, and uterus. HAC was first characterized in the stomach and two criteria were proposed for its diagnosis: (a) a portion of the tumor must consists of cells that resemble HCC histologically and (b) the tumor must be producing

Hepatoid adenocarcinoma of the lung.

Hepatoid adenocarcinoma of lung (HAL) is a rare and aggressive tumor. The current study reported a new HAL case in the right lower lung with high serum α-fetoprotein (AFP) level in a 71-year-old male patient. After the confirmation of morphology and immunohistochemistry, the patient was diagnosed clinically with HAL and treated with radio-frequency ablation. However, the patient whose disease progressed eventually died 4 months after diagnosis. Whole genome sequencing analysis identified a driver gene mutation in the FAT atypical cadherin 1 gene (FAT1) and the copy number loss. The tumor was microsatellite-stable and tumor mutation burden (TMB) was 1.69 mutations/Mb. PD-L1 expression was negative by IHC. Our finding provide further clues for the molecular basis of HAL and the efficacy of immunotherapy needs to be explored.

/pdf/genomic-profiles-of-a-patient-of-pulmonary-hepatoid-51m7kfcvwf.pdf

Genomic Profiles of a Patient of Pulmonary Hepatoid Adenocarcinoma With High AFP Level: A Case Report.

Background Hepatoid adenocarcinoma (HAC) occurs in extrahepatic organs such as the gastrointestinal tract, testes, ovaries, lungs, mediastinum and pancreas, and frequently produces α-fetoprotein (AFP). HAC of the lung (HAL) is rare, characterized by difficult treatment and poor prognosis. There are no reports of HAL in Yunnan-Guizhou Plateau, China. Case summary A 60-year-old male patient was clinically diagnosed with HAL pT3N0M0, stage IIB. Chest computed tomography revealed a 7.5 cm × 7.2 cm soft tissue mass located in the right lung upper lobe and the adjacent superior mediastinum. Right upper lobectomy was performed. The diagnosis of HAL was confirmed by pathological examination, and the patient received paclitaxel and carboplatin as adjuvant chemotherapy after surgery. Conclusion Clinical manifestations, pathological features, imaging findings, auxiliary examination, and treatment planning of HAL are presented to help clinicians improve their diagnosis and treatment.

Primary hepatoid adenocarcinoma of the lung in Yungui Plateau, China: A case report

Hepatoid adenocarcinoma of the lung (HAL) is a rare type of extrahepatic hepatoid adenocarcinoma. The majority of such cases that have been reported in the English literature have demonstrated elevated serum α-fetoprotein (AFP) and/or positive AFP expression on histopathological analysis, and have had poor prognoses. The current study reports an extremely rare case of HAL in the right upper lung without AFP production in a 59-year-old male patient. The patient underwent radical right upper lobectomy via video assisted thoracoscopic surgery. No signs of local recurrence or distant metastasis have been observed for 23 months after the surgery. The serum AFP level following surgery remained within the normal range. Although the diagnosis of HAL predominantly depends on pathological examination, a review of the literature demonstrates that HAL has certain characteristic features with regard to its clinical and computed tomography findings and prognoses, and clinicians should be aware that clinicians should be aware that monitoring serum AFP levels, as well as CT findings, remains important.

/pdf/hepatoid-adenocarcinoma-of-the-lung-without-production-of-a-4hrozoxesq.pdf

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

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Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature