Lin Gao
University of Pennsylvania
15 Papers
239 Citations
Lin Gao is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cell polarity & PDZ domain. The author has an hindex of 13, co-authored 14 publications. Previous affiliations of Lin Gao include Johns Hopkins University School of Medicine & University of Virginia.
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Papers
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.
TL;DR: The identification of a biochemical and functional link between these two complexes that is mediated by Par6 and PALS1 is highlighted, highlighting a previously unrecognized link between protein complexes that are essential for epithelial polarity and formation of tight junctions.
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Cell polarity triggered by cell-cell adhesion via E-cadherin.
Ravi A. Desai,Lin Gao,Srivatsan Raghavan,Srivatsan Raghavan,Wendy Liu,Wendy Liu,Christopher S. Chen +6 more
TL;DR: A novel role for cell-cell adhesion in polarization is demonstrated, and have implications for wound healing and developmental patterning.
Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6
TL;DR: It is shown that Par6 inhibits TJ assembly in MDCK II epithelial cells after their disruption by Ca(2+) depletion but does not inhibit adherens junction (AJ) formation, suggesting that Cdc42 and Par6 negatively regulate TJAssembly in mammalian epithelial Cells.
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Activation of beta 1 but not beta 3 integrin increases cell traction forces
Grace L. Lin,Daniel M. Cohen,Ravi A. Desai,Mark T. Breckenridge,Lin Gao,Martin J. Humphries,Christopher S. Chen +6 more
TL;DR: It is reported that activation of β1 but not β3 integrin, by either increasing density of immobilized fibronectin or treating with manganese, elicited fibroblast spreading and cytoskeletal tension, suggesting that integrin activation and cell traction forces comprise a bi‐directional signaling unit of cell adhesion.
82
Adhesion Regulates MAP Kinase/Ternary Complex Factor Exchange to Control a Proliferative Transcriptional Switch
Michele A. Wozniak,Catherine Q. Cheng,Colette J. Shen,Lin Gao,Anthony O. Olarerin-George,Kyoung-Jae Won,John B. Hogenesch,Christopher S. Chen +7 more
TL;DR: A key role for the TCFs is demonstrated in adhesion-induced transcription and proliferation and a novel MAPK/TCF transcriptional switch that controls this process is revealed.
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