Lin Fan
Tongji University
6 Papers
4 Citations
Lin Fan is an academic researcher from Tongji University. The author has contributed to research in topics: Mycobacterium & Mycobacterium tuberculosis. The author has an hindex of 1, co-authored 3 publications.
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Papers
Mycobacterium tuberculosis PE_PGRS1 promotes mycobacteria intracellular survival via reducing the concentration of intracellular free Ca2+ and suppressing endoplasmic reticulum stress.
TL;DR: Wang et al. as discussed by the authors identified that PE_PGRS1 is a novel calcium-associated protein that can decrease intracellular Ca2+ levels and the PERK axis, which can mitigate the activation of PERK branch in endoplasmic reticulum (ER) stress by downregulating the expression of CHOP, Bip, pPERK, p-eIF2α, and ATF4.
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Mycobacterium Von Willebrand factor protein MSMEG_3641 is involved in biofilm formation and intracellular survival.
Xiaokang Zhao,Xiangke Duan,Yongdong Dai,Junfeng Zhen,Jiaohan Guo,Ke Zhang,Xiaoyu Wang,Zhongmei Kuang,Hao Wang,Jingjing Niu,Lin Fan,Jianping Xie +11 more
TL;DR: This is the first report concerning the mycobacteria Von Willebrand factor domain function, especially in colony morphology and biofilm development, and it is found that mutation of MSMEG_3641, a homolog of M. tuberculosis Rv1836c, can change M. smegmatis colony morphologyand biofilm.
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Mycobacterium tuberculosis Rv1515c antigen enhances survival of M. smegmatis within macrophages by disrupting the host defence.
Wenmin Yang,Minqiang Liu,Xi Yu,Yu Huang,Jie Zeng,Yongdong Dai,Hongping Luo,Qinqin Huang,Lin Fan,Jianping Xie +9 more
TL;DR: In this article, the authors focused on Rv151515c, an RD6 member from M. tuberculosis, and characterised it as a cell surface-associated protein that functions in disrupting the cytokine profile and promoting endoplasmic reticulum stress-mediated apoptosis.
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Mycobacterium Lrp/AsnC family transcriptional factor modulates the arginase pathway as both a sensor and a transcriptional repressor.
Shuangquan Yan,Junfeng Zhen,Yuzhu Li,Yu Huang,Xuefeng Ai,Yue Li,Andrea Stojkoska,Xue Huang,Cao Ruan,Jiang Li,Lin Fan,Jianping Xie +11 more
TL;DR: The results uncover a unique regulatory mechanism of arginine metabolism in mycobacteria and identify M. tb Rv2324 as an attractive candidate target for the design of drugs against tuberculosis.
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Improving the identification and diagnostic efficiency of Metagenomic Next-Generation Sequencing for mycobacterial granuloma on postoperative formalin-fixed paraffin-embedded specimens.
TL;DR: The mNGS could be used for one-time detection of pathogens on FFPE sections with high sensitivity and could be recommended as a supplementary method for the identification of pathogenic bacteria in the diagnosis of postoperative granuloma lesions.
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