Lin Chen
BioMarin Pharmaceutical
6 Papers
87 Citations
Lin Chen is an academic researcher from BioMarin Pharmaceutical. The author has contributed to research in topics: Identification (biology) & Glycopeptide. The author has an hindex of 3, co-authored 5 publications.
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Papers
Development of Pegylated Forms of Recombinant Rhodosporidium toruloides Phenylalanine Ammonia-Lyase for the Treatment of Classical Phenylketonuria
Alejandra Gámez,Christineh N. Sarkissian,Lin Wang,Woomi Kim,Mary Straub,Marianne G. Patch,Lin Chen,Steve Striepeke,Paul A. Fitzpatrick,Jeffrey F. Lemontt,Charles A. O'Neill,Charles R. Scriver,Raymond C. Stevens +12 more
TL;DR: From a series of formulations of linear and branched polyethylene glycols chemically conjugated to PAL, a parenteral therapeutic agent for PKU treatment is created, suggesting potential as a novel PKU therapeutic.
72
Patent
Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
Minmin Qin,John M. Henstrand,Gary N Zecherle,Dan J Wendt,Wai-Pan Chan,Lin Chen,Paul A. Fitzpatrick,Christopher M. Starr,Stuart J. Swiedler +8 more
- 07 Nov 2003
TL;DR: In this paper, a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations were provided.
15
De-sialylation of glycopeptides by acid treatment: enhancing sialic acid removal without reducing the identification.
Wenbo Dong,Huanhuan Liu,Zexuan Chen,Lin Chen,Li Jia,Jiechen Shen,Bojing Zhu,Pengfei Li,Daidi Fan,Shian Sun +9 more
TL;DR: It is found that most commonly used chemical methods couldn't completely remove sialic acids from glycopeptides, and by adding the deamidation on carbamidomethyl-cysteine, asparagine, and glutamine residues as a variable modification during database search, most of the unidentified spectra could be recovered.
3
Patent
Methods for producing and purifying recombinant alpha-L-iduronidase
Minmin Qin,Wai-Pan Chan,Lin Chen,Paul A. Fitzpatrick,John M. Henstrand,Dan J Wendt,Gary N Zecherle,Christopher M. Starr,Emil D. Kakkis +8 more
- 09 Nov 2001
TL;DR: In this article, a recombinant human α-L-iduronidase and biologically active fragments and muteins thereof with a purity greater than 99% were provided, and large-scale methods to produce and purify commercial grade recombinant HIDase enzyme thereof.
1
Patent
Wet chemistry process for manufacturing semiconductor device with increased channel mobility
ダール，サリット,Sarit Dhar,チェン，リン,Lin Chen,リュー，セイ−ヒュン,Sei-Hyung Ryu,アガーワル，アナント・クマール,Anant K. Agarwal,パルマー，ジョン・ウィリアムズ,John W. Palmour,マキ，エリック,Maki Erik,ガーゲイナス，ジェイソン,Gurganus Jason,リキテンウォルナー，ダニエル・ジェナー,Daniel J. Lichtenwalner +15 more
- 26 Aug 2016
TL;DR: In this article, the authors proposed a gate stack with either barium (Ba) or strontium (Sr) metal for increased channel mobility using alkali earth metal.