Lin Chen
Cornell University
8 Papers
80 Citations
Lin Chen is an academic researcher from Cornell University. The author has contributed to research in topics: Migrastatin & Cell migration. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Lin Chen include National Institutes of Health.
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Papers
Migrastatin analogues target fascin to block tumour metastasis
TL;DR: It is shown that migrastatin analogues target the actin-bundling protein fascin to inhibit its activity, demonstrating that actin cytoskeletal proteins such as fascin can be explored as new molecular targets for cancer treatment, in a similar manner to the microtubule protein tubulin.
Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
Dandan Shan,Lin Chen,Jon T. Njardarson,Christoph Gaul,Xiaojing Ma,Samuel J. Danishefsky,Xin-Yun Huang +6 more
TL;DR: It is demonstrated that two, fully synthetic migrastatin analogues, core macroketone and core macrolactam, are potent inhibitors of metastasis in a murine breast tumor model and could be used in cancer-therapy strategies.
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Erratum: Migrastatin analogues target fascin to block tumour metastasis
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous work.
Molecular mechanism of fascin function in filopodial formation
Shengyu Yang,Fang-Ke Huang,Jianyun Huang,Shuai Chen,Jean Jakoncic,Alejandra Leo-Macias,Ruben Diaz-Avalos,Lin Chen,J. Jillian Zhang,Xin-Yun Huang +9 more
TL;DR: There are two major actin-binding sites on fascin and there is a concerted conformational changes in fascin from inactive to active states in the process of actin bundling, revealing the molecular mechanism of fascin function in filopodial formation.
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The G Protein Gα13 Is Required for Growth Factor-Induced Cell Migration
TL;DR: It is shown that a heterotrimeric G protein, G alpha(13), is essential for RTK-induced migration of mouse fibroblast and endothelial cells and appears to be a critical signal transducer forRTKs as well as GPCRs.
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