Lin Chen
Sun Yat-sen University
17 Papers
Lin Chen is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Medicine. The author has an hindex of 6, co-authored 17 publications.
Chat about Author
Papers
Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial.
You-Ping Liu,Yihui Wen,Jun Tang,Yi Wei,Rui You,Xiaolin Zhu,Jian Li,Lin Chen,Li Ling,Ning Zhang,Xiong Zou,Yi-Jun Hua,You-Mou Chen,Lei Chen,Li-Xia Lu,Ming-Yuan Chen,Weiping Wen +16 more
TL;DR: In this paper, the authors compared the efficacy and safety outcomes of salvage endoscopic surgery versus intensity-modulated radiotherapy (IMRT) in patients with resectable locally recurrent NCC.
126
A positive-feedback loop between tumour infiltrating activated Treg cells and type 2-skewed macrophages is essential for progression of laryngeal squamous cell carcinoma.
Wei Sun,Fanqin Wei,Wei-Jin Li,Jia-Wei Wei,Hua Zhong,Yihui Wen,Wenbin Lei,Lin Chen,Hang Li,Han-qing Lin,Muhammad Iqbal,Weiping Wen +11 more
TL;DR: The positive-feedback loop between aTreg cells and M2 macrophages is essential to maintain or promote immunosuppression in the tumour microenvironment and may be a potential therapeutic target to inhibit tumour progression.
Stromal interleukin-33 promotes regulatory T cell-mediated immunosuppression in head and neck squamous cell carcinoma and correlates with poor prognosis.
Yihui Wen,Han-qing Lin,Hang Li,Yi Zhao,Vivian Wai Yan Lui,Lin Chen,Xing-mei Wu,Wei Sun,Weiping Wen +8 more
TL;DR: Stromal IL-33 both expands the Treg population and enhances their functions in the tumor microenvironment and has prognostic value for tumor progression, which makes it a potential target for future HNSCC immunotherapy.
51
Ferroptosis Driver SOCS1 and Suppressor FTH1 Independently Correlate With M1 and M2 Macrophage Infiltration in Head and Neck Squamous Cell Carcinoma.
TL;DR: In this paper, the role of ferroptosis, an iron-dependent form of non-apoptotic cell death, in the head and neck squamous cell carcinoma (HNSCC) immune microenvironment was investigated.
Long Noncoding RNA GAS5 Acts As A Tumor Suppressor In Laryngeal Squamous Cell Carcinoma Via miR-21.
Kexing Lyu,Yang Xu,Huijun Yue,Yun Li,Jing Zhao,Lin Chen,Jianhui Wu,Xiaolin Zhu,Liping Chai,Chunwei Li,Weiping Wen,Wenbin Lei +11 more
TL;DR: GAS5 suppresses LSCC progression through the negative regulation of miR-21 and its targets involved in cell proliferation and apoptosis, indicating that GAS5 may serve as a biomarker and potential target for LSCC therapy.