Limin Chai
Xi'an Jiaotong University
26 Papers
83 Citations
Limin Chai is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Cancer & Signal transduction. The author has an hindex of 8, co-authored 26 publications.
Chat about Author
Papers
ERK/Drp1-dependent mitochondrial fission contributes to HMGB1-induced autophagy in pulmonary arterial hypertension.
Wei Feng,Jian Wang,Xin Yan,Qianqian Zhang,Limin Chai,Qingting Wang,Wenhua Shi,Yuqian Chen,Jin Liu,Zhan Qu,Shaojun Li,Xinming Xie,Manxiang Li +12 more
TL;DR: In this paper, highmobility group box-1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin-related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) and critically implicated in PAH pathogenesis.
82
Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation.
Cui Zhai,Wenhua Shi,Wei Feng,Yanting Zhu,Jian Wang,Shaojun Li,Xin Yan,Qingting Wang,Qianqian Zhang,Limin Chai,Cong Li,Pengtao Liu,Manxiang Li +12 more
TL;DR: NF‐&kgr;B‐induced autophagy activation and consequent down‐regulation of RND3 contributes to the development of PAH in MCT‐treated rats.
63
Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms
Yilin Pan,Lu Liu,Shaojun Li,Ke Wang,Rui Ke,Wenhua Shi,Jian Wang,Xin Yan,Qianqian Zhang,Qingting Wang,Limin Chai,Xinming Xie,Manxiang Li +12 more
TL;DR: The study suggests that activation of AMPK modulates miR-206/HDAC4/cyclin D1 signaling pathway, particularly targeting on HDAC4, to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by alleviating airway remodeling.
Resveratrol inhibits monocrotaline-induced pulmonary arterial remodeling by suppression of SphK1-mediated NF-κB activation.
Wenhua Shi,Cui Zhai,Wei Feng,Jian Wang,Yanting Zhu,Shaojun Li,Qingting Wang,Qianqian Zhang,Xin Yan,Limin Chai,Pengtao Liu,Yuqian Chen,Manxiang Li +12 more
TL;DR: SphK1 protein level, S1P production, NF‐&kgr;B activation and cyclin D1 expression were significantly increased in MCT‐induced PAH rats, indicating that resveratrol might be a therapeutic agent for the prevention of PAH.
46
Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis
Cui Zhai,Shaojun Li,Wei Feng,Wenhua Shi,Jian Wang,Qingting Wang,Limin Chai,Qianqian Zhang,Xin Yan,Manxiang Li +9 more
TL;DR: The results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.
33