Lihui Wang
National Institutes of Health
7 Papers
17 Citations
Lihui Wang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chemistry & Viral entry. The author has an hindex of 5, co-authored 5 publications.
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Papers
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
Qi Zhang,Catherine Z. Chen,Manju Swaroop,Miao Xu,Lihui Wang,Juhyung Lee,Amy Wang,Manisha Pradhan,Natalie Hagen,Lu Chen,Min Shen,Zhiji Luo,Xin Xu,Yue Xu,Wenwei Huang,Wei Zheng,Yihong Ye +16 more
TL;DR: HS is established as an attachment factor that assists SARS coronavirus cell entry and reveals drugs capable of targeting this important step in the viral life cycle.
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis
Lihui Wang,Yue Xu,Heather Rogers,Layla F. Saidi,Constance Tom Noguchi,Honglin Li,Jonathan W. Yewdell,Nicholas R. Guydosh,Yihong Ye +8 more
TL;DR: It is proposed that in metazoan, co-translational protein translocation into the ER is safeguarded by a UFMylation-dependent protein quality control mechanism, which when impaired causes anemia in mice and abnormal neuronal development in humans.
Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro
Qi Zhang,Catherine Z. Chen,Manju Swaroop,Miao Xu,Lihui Wang,Juhyung Lee,Amy Wang,Manisha Pradhan,Natalie Hagen,Lu Chen,Min Shen,Zhiji Luo,Xin Xu,Yue Xu,Wenwei Huang,Wei Zheng,Yihong Ye +16 more
TL;DR: HS is established as an attachment factor that assists SARS coronavirus cell entry, and drugs capable of targeting this important step in the viral life cycle are revealed.
DNAJC5 facilitates USP19-dependent unconventional secretion of misfolded cytosolic proteins
TL;DR: A transcellular protein quality control regulatory pathway in which a deubiquitinase-chaperone axis forms a “triaging hub”, transferring aberrant polypeptides from stressed cells to healthy ones for disposal is suggested.
Targeting heparan sulfate proteoglycan-assisted endocytosis as a COVID-19 therapeutic option
Qi Zhang,Catherine Z. Chen,Manju Swaroop,Miao Xu,Lihui Wang,Juhyung Lee,Manisha Pradhan,Min Shen,Zhiji Luo,Yue Xu,Wenwei Huang,Wei Zheng,Yihong Ye +12 more
TL;DR: HSPGs are established as an assisting factor for ACE2 in endocytosis-mediated coronavirus entry and drugs that can be repurposed to target this important stage in the viral life cycle are identified.