Lidia Maciag
Memorial Sloan Kettering Cancer Center
4 Papers
Lidia Maciag is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Somatic hypermutation & Concordance. The author has an hindex of 2, co-authored 2 publications.
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Papers
Quantification of Measurable Residual Disease Detection by Next Generation Sequencing-based Clonality Testing in B-cell and Plasma Cell Neoplasms.
Ying Liu,Caleb Ho,Wayne Yu,Ying Huang,Jeffrey Miller,Qi Gao,Mustafa Syed,Yuanyuan G. Ma,Meiyi Wang,Lidia Maciag,Kseniya Petrova-Drus,Menglei Zhu,Jinjuan Yao,Chad Vanderbilt,Benjamin Durham,Jamal Benhamida,Mark D. Ewalt,Ahmet Dogan,Mikhail Roshal,Khedoudja Nafa,Maria E. Arcila +20 more
TL;DR: This NGS-based MRD assay showed highly reproducible results with quantitation that correlated well with FC MRD assessment, particularly for B-cell neoplasms, and showed highly concordant MRD detection and quantitation.
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Clonal Characterization and Somatic Hypermutation (SHM) Assessment by Next Generation Sequencing in Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma (CLL/SLL): A Detailed Description of the Technical Performance, Clinical Utility, and Platform Comparison.
Kseniya Petrova-Drus,Mustafa H Syed,Wayne Yu,Kasey R. Hutt,A. M. Zlotnicki,Ying Huang,Monika Kamalska-Cyganik,Lidia Maciag,Meiyi Wang,Yuanyuan G. Ma,Caleb Ho,Christine Moung,Jinjuan Yao,Khedoudja Nafa,Jee-Sun Baik,Chad M. Vanderbilt,Jamal Benhamida,Yingmei Liu,Menglei Zhu,Benjamin H. Durham,Mark D. Ewalt,Paulo Salazar,Ivelise Rijo,Tessara Baldi,Anthony R. Mato,Lindsey E. Roeker,Mikhail Roshal,Ahmet Dogan,Maria E. Arcila +28 more
TL;DR: In this paper , a comparison of two platforms (Ion Torrent versus Illumina) and two primer sets [leader versus framework region 1 (FR1)] in their ability to identify clonotypic IGHV rearrangement(s) revealed 97% concordance.
Routine Evaluation of Minimal Residual Disease in Myeloma Using Next-Generation Sequencing Clonality Testing: Feasibility, Challenges, and Direct Comparison with High-Sensitivity Flow Cytometry.
Caleb Ho,Mustafa H Syed,Mikhail Roshal,Kseniya Petrova-Drus,Christine Moung,Jinjuan Yao,Andrés E. Quesada,Jamal Benhamida,Chad M. Vanderbilt,Ying Liu,Menglei Zhu,Wayne Yu,Lidia Maciag,Meiyi Wang,Yuanyuan Ma,Qi Gao,Even H Rustad,Malin Hultcrantz,Benjamin Diamond,Binbin Zheng-Lin,Ying Huang,Kasey Hutt,Jeffrey E. Miller,Ahmet Dogan,Khedoudja Nafa,Ola Landgren,Maria E. Arcila +26 more
TL;DR: This large, single-institution study including 438 samples from 251 patients, the use of NGS targeting the IGH and IGK genes for clonal characterization and monitoring, with comparison to hsFC, is described.
Establishment of Immunoglobulin Heavy (IGH) Chain Clonality Testing by Next-Generation Sequencing for Routine Characterization of B-Cell and Plasma Cell Neoplasms.
Maria E. Arcila,Wayne Yu,Mustafa H Syed,Hannah Kim,Lidia Maciag,Jinjuan Yao,Caleb Ho,Kseniya Petrova,Christine Moung,Paulo Salazar,Ivelise Rijo,Tessara Baldi,Ahmet Zehir,Ola Landgren,Jae H. Park,Mikhail Roshal,Ahmet Dogan,Khedoudja Nafa +17 more
TL;DR: Routine NGS clonality assessment is feasible and superior to existing assays, enabling accurate and specific index clone assessment and future tracking of all rearrangements in a patient sample, which should be performed as a multicenter and multidisciplinary collaboration.