Lidia E. Costa
University of Buenos Aires
15 Papers
124 Citations
Lidia E. Costa is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Nitric oxide & Nitric oxide synthase. The author has an hindex of 10, co-authored 14 publications.
Chat about Author
Papers
Long-term angiotensin II inhibition increases mitochondrial nitric oxide synthase and not antioxidant enzyme activities in rat heart.
Lidia E. Costa,Pablo La-Padula,Silvia Lores-Arnaiz,Gabriela D'Amico,Alberto Boveris,Maria Luisa Kurnjek,Nidia Basso +6 more
TL;DR: Results do not support the hypothesis of an increase in antioxidant enzyme activity by long-term treatment with angiotensin II inhibitors and point towards a role for the NO produced by mitochondrial nitric oxide synthase (mtNOS) in the protective effect of these drugs.
56
Effect of sustained hypobaric hypoxia during maturation and aging on rat myocardium. I. Mechanical activity
TL;DR: Results are consistent with the development of cardioprotection during high-altitude acclimatization and provide an experimental model to study the mechanisms involved, which are addressed in the accompanying paper.
51
Free radical chemistry in biological systems
Laura B. Valdez,Silvia Lores Arnaiz,Juanita Bustamante,Silvia Alvarez,Lidia E. Costa,Alberto Boveris +5 more
TL;DR: The balance between NO production and its utilization results in a NO intramitochondrial steady-state concentration of 20-50 nM, which regulates mitochondrial O2 uptake and energy supply.
46
Free radical chemistry in biological systems
Laura B. Valdez,Silvia Lores Arnaiz,Juanita Bustamante,Silvia Alvarez,Lidia E. Costa,Alberto Boveris +5 more
- 02 May 2019
TL;DR: The regulation of cellular respiration and energy production by NO and its ability to switch the pathway of cell death from apoptosis to necrosis in physiological and pathological conditions could take place primarily through the inhibition of mitochondrial ATP production.
37
Time course of regression of the protection conferred by simulated high altitude to rat myocardium: correlation with mtNOS.
TL;DR: This experimental model would provide the most persistent effect known at present on preservation of myocardial mechanical activity and improved tolerance to O(2) deprivation and support the putative role of mtNOS in the mechanism involved.
16