Lichu Liu

TL;DR: It is shown that aged‐related deficits in direct bone formation can be restored to young mice by treatment with TNF blockers and that the cyclin‐dependent kinase inhibitor p21 is a candidate for mediation of the osteoinhibitory effects of TNF.

TL;DR: The findings suggest that the Zucker Diabetic Fatty rats model might be used to study the contributions of leptin resistance, insulin resistance and/or hyperglycemia to impaired osteoblastogenesis in vivo.

TL;DR: It is demonstrated that CDP has profound short term negative effects on the process of bone repair in DO, which provides the mechanistic basis for modeling peri‐operative chemotherapy doses and schedules and may provide new opportunities to identify molecules that spare normal cells from the inhibitory effects of CDP.

TL;DR: This model can be used to study the mechanisms underlying inhibition of bone formation by chronic ethanol exposure and to test preclinical interventions and is supported by radiographic and histologic analyses of the % new bone formation in the DO gaps.