Lichong Xu
Pennsylvania State University
11 Papers
Lichong Xu is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 1 publications.
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Papers
β-Cyclodextrin-poly(β-Amino Ester) Nanoparticles for Sustained Drug Delivery across the Blood–Brain Barrier
TL;DR: The developed β-cyclodextrin-poly(β-amino ester) nanoparticles might be useful as drug carriers for transporting drugs across the BBB to treat chronic diseases in the brain.
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Submicron topography design for controlling staphylococcal bacterial adhesion and biofilm formation.
TL;DR: It appears that the design of textured patterns should minimize surface area fraction to reduce the bacterial interaction with surfaces but in a way that ensures the mechanical strength of pillars in order to avoid collapse.
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Surface texturing and combinatorial approaches to improve biocompatibility of implanted biomaterials
TL;DR: In this article , the authors discuss the development of surface texturing techniques utilizing ordered submicron-size pillars for controlling bacterial adhesion and biofilm formation, and present combinatorial approaches utilizing surface texturization in combination with poly (ethylene glycol) (PEG) grafting and NO release to improve the biocompatibility of biomaterials.
Nucleotide Messenger Signaling of Staphylococci in Responding to Nitric Oxide - Releasing Biomaterials.
TL;DR: In this paper , the authors investigated the cyclic nucleotide second messengers c-di-GMP, cyclic dimeric guanosine monophosphate (c-DI-AMP), and cyclic adenosine mono-phosphate(cAMP) in both Staphylococcus aureus (S. epidermidis) RP62A after incubating with S-nitroso-N-acetylpenicillamine (SNAP, NO donor) impregnated polyurethane (PU) films.
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In Vivo Assessment of Dual-Function Submicron Textured Nitric Oxide Releasing Catheters in a 7-Day Rabbit Model.
Yi Wu,Lichong Xu,Eric Yeager,K. G. Beita,Natalie Crutchfield,Sarah N. Wilson,Patrick Maffe,Chad Schmiedt,Christopher A. Siedlecki,Hitesh Handa +9 more
TL;DR: A biocompatible and robust dual-functioning textured nitric oxide (NO) polyurethane catheter is demonstrated in limiting fouling-induced complications for longer-term blood-contacting device applications and illustrates that NO-textured catheter surface mitigates foreign body response.
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