Licheng Wu
University of Chicago
16 Papers
37 Citations
Licheng Wu is an academic researcher from University of Chicago. The author has contributed to research in topics: Pseudomonas aeruginosa & Tight junction. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of Licheng Wu include University of Illinois at Chicago.
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Papers
Recognition of host immune activation by Pseudomonas aeruginosa
Licheng Wu,Oscar Estrada,Olga Zaborina,Manjeet Bains,Le Shen,Jonathan E. Kohler,Nachiket Patel,Mark W. Musch,Eugene B. Chang,Yang Xin Fu,Michael A. Jacobs,Michael I. Nishimura,Robert E. W. Hancock,Jerrold R. Turner,John C. Alverdy +14 more
TL;DR: It is demonstrated that interferon-γ binds to an outer membrane protein in Pseudomonas aeruginosa, OprF, resulting in the expression of a quorum-sensing dependent virulence determinant, the PA-I lectin, which provides details of the mechanisms by which prokaryotic organisms are directly signaled by immune activation in their eukaryotic host.
337
Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function.
David R. Raleigh,Devin M. Boe,Dan Yu,Christopher R. Weber,Amanda M. Marchiando,Emily M. Bradford,Yingmin Wang,Licheng Wu,Eveline E. Schneeberger,Le Shen,Jerrold R. Turner +10 more
TL;DR: Occludin S408 phosphorylation regulates interactions between occlUDin, ZO-1, and select claudins to define tight junction molecular structure and barrier function.
235
Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression
Wei-Ting Kuo,Le Shen,Li Zuo,Li Zuo,Nitesh Shashikanth,Ma. Lora Drizella M. Ong,Licheng Wu,Juanmin Zha,Juanmin Zha,Karen L. Edelblum,Karen L. Edelblum,Yitang Wang,Yingmin Wang,Steven P. Nilsen,Jerrold R. Turner,Jerrold R. Turner +15 more
TL;DR: Reduced levels of occludin and CASP3 in intestinal epithelial cells of patients with inflammatory bowel diseases might promote restoration of mucosal homeostasis in response to inflammatory conditions.
177
The impact of stress and nutrition on bacterial-host interactions at the intestinal epithelial surface.
TL;DR: With a better understanding of the bacteria–host interactions in health and the alterations induced by critical illness, new therapies that improve the environment of both may lead to better recovery rates in intensive care unit patients.
102
Identification of multi-drug resistant Pseudomonas aeruginosa clinical isolates that are highly disruptive to the intestinal epithelial barrier
Olga Zaborina,Jonathan E. Kohler,Yingmin Wang,Cindy Bethel,Olga Shevchenko,Licheng Wu,Jerrold R. Turner,John C. Alverdy +7 more
TL;DR: Detailed phenotypic analysis of the behavior of multi-drug resistant P. aeruginosa against the intestinal epithelium has the potential to identify strains most likely to place patients at risk for lethal gut-derived sepsis.