Lichan Yuan
Nanjing Medical University
12 Papers
6 Citations
Lichan Yuan is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Chemistry & Osteoclast. The author has an hindex of 3, co-authored 9 publications.
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Papers
The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway.
Huimin Chen,Shuyu Guo,Yang Xia,Lichan Yuan,Mengting Lu,Meng Zhou,Mengru Fang,Li Meng,Zhongdang Xiao,Junqing Ma +9 more
TL;DR: The role of Trio, a GTP exchange factor, in tooth development is determined and the p38 MAPK pathway was found to be involved in Trio related root deformity.
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Integrated Cascade Nanozyme Remodels Chondrocyte Inflammatory Microenvironment in Temporomandibular Joint Osteoarthritis via Inhibiting ROS‐NF‐κB and MAPK Pathways
TL;DR: In this paper , the Pt@PCN222-Mn cascade nanozyme was applied to the treatment of temporomandibular joint osteoarthritis (TMJ OA).
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Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.
Meng Zhou,Shuyu Guo,Lichan Yuan,Yuxin Zhang,Mengnan Zhang,Huimin Chen,Mengting Lu,Jianrong Yang,Junqing Ma +8 more
TL;DR: Downregulation of LGR4 gene expression inhibited SCAPs proliferation, migration and odonto/osteogenic differentiation by blocking the Wnt/β-catenin signaling pathway, indicating that L GR4 might play a vital role in SCAP’s proliferation and odontoblastic differentiation.
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Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2.
TL;DR: It is reported for the first time that the expression of Pax2 gradually increased during osteogenic differentiation of mouse MSCs, and osteoprogenitor cells, suggesting that Pax2 has a role in the pathophysiology of bone related diseases, and has potential application in bone tissue regeneration.
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Trio cooperates with Myh9 to regulate neural crest-derived craniofacial development
Shuyu Guo,Li Meng,Haojie Liu,Lichan Yuan,Na Zhao,Jieli Ni,Yang Zhang,Jingjing Ben,Yi-Ping Li,Junqing Ma +9 more
TL;DR: Trio is a unique member of the Rho-GEF family that has three catalytic domains and is vital for various cellular processes in both physiological and developmental settings as discussed by the authors.
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