Liang Ye
Yantai University
12 Papers
69 Citations
Liang Ye is an academic researcher from Yantai University. The author has contributed to research in topics: Medicine & Prolactin. The author has an hindex of 7, co-authored 12 publications.
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Papers
Antitumor effect and toxicity of Lipusu in rat ovarian cancer xenografts.
TL;DR: Antitumor effects, bone marrow toxicity, cardiotoxicity and biodistributions in NuTu19 ovarian cancer-bearing rats, as well as the abdominalpain in normal mice were evaluated, suggesting that Lipusu has similar antitumor effect and superior lymphatic targeting with reduced toxicities compared with PTX via i.p. route.
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Antidepressant-like effects of the extract from Cimicifuga foetida L.
TL;DR: Data indicate XMT processes antidepressant-like properties in rodents, which could be related to its serotonergic and noradrenergic activation and normalization of the hypothalamic-pituitary-adrenal axis.
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The discovery of tetrahydropyridine analogs as hNav1.7 selective inhibitors for analgesia.
Wu Wentao,Li Zhixiang,Guangwen Yang,Teng Mingxing,Jian Qin,Zhijing Hu,Lijuan Hou,Liang Shen,Haiheng Dong,Yang Zhang,Jian Li,Chen Shuhui,Jingwei Tian,Jianzhao Zhang,Liang Ye +14 more
TL;DR: The design and synthesis of a novel series of tetrahydropyridine analogs as hNav1.7 inhibitors for analgesia are reported, resulting in the identification of compound (-)-15h, a highly potent and selective hNav 1.7 inhibitor with good ADME and PK profiles.
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Protection of pyruvate against glutamate excitotoxicity is mediated by regulating DAPK1 protein complex.
Jingwei Tian,Jucan Cheng,Jianzhao Zhang,Liang Ye,Fangxi Zhang,Qiuju Dong,Hongbo Wang,Fenghua Fu +7 more
TL;DR: A novel mechanism that pyruvate prevents SH-SY5Y cells from glutamate excitotoxicity by regulating death-associated protein kinase 1 (DAPK1) protein complex is reported.
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Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicity and IFN-γ production
TL;DR: These results suggested the IL18-IL2 fusion protein showed a synergetic effect on tumor regression, which was related to the great ability of IL18 -IL2 in enhancing IFN-γ production and natural killer cell cytotoxicity.
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