The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components.

Methods and compositions for separating rare cells from fluid samples

A microfluidic device can include: a channel; a fluid inlet to pass fluid into the channel from a reservoir; a sensor disposed in the channel; and a pump actuator disposed in the channel apart from the sensor to induce fluid flow into the channel.

Microfluidic sensing device and system

Systems and methods are described for analyzing a plurality of biological samples with a plurality of fluorescent reagents in an automated fashion. The system may include two optical systems, a fluorescence imaging system and an optical quenching system. These two systems may be placed laterally adjacent to one another, and generally beneath one of the wells of sample-containing microtiter plate. The biological sample contained therein may be stained with a series of fluorescent reagents, with the fluorescence quenched between stainings. By precise positioning of the sample with respect to the imaging system, the sample may be imaged with a plurality of serially applied reagents.

Automated analysis tool for biological specimens

Microfluidic chip for biological chemiluminescence detection and manufacturing method thereof

The invention relates to a determination device for the Seebeck coefficient of a flexible thin film material. The determination device comprises an infrared thermal imager, a sample to be measured, a heating assembly, a vacuum pump, a direct-current power supply, wires, a digital source, electrodes, a thermal dissipation assembly, a vacuum box, an infrared window, a base and a support; the vacuum box is installed on the base, the infrared window is arranged on the top of the vacuum box, the heating assembly and the thermal dissipation assembly are installed on the positions, in the vacuum box, of the base and used for suspending the sample to be measured, the vacuum pump connected with the vacuum box is installed at the side of the base and used for ensuring that the sample to be measured is located in a vacuum environment, the infrared thermal imager is installed on the base through the support and located over the infrared window, the direct-current power supply is connected with the heating assembly and used for supplying power to the heating assembly, and the digital source is connected with the two ends of the sample to be measured through the wires and the electrodes. The determination device is simple in structure, easy and convenient to operate, low in cost and suitable for being easily used and popularized in the industrial field and the scientific research field.

Determination device for Seebeck coefficient of flexible thin film material

The invention discloses an integrated micro-fluidic chip system, which comprises a micro-fluidic chip, a light source unit, a sample introduction unit, a detection unit and a communication unit, wherein the micro-fluidic chip is connected with the light source unit through optical fibers and connected with the sample introduction unit through a hose; and the communication unit is electrically connected with the detection unit, the light source unit and the sample introduction unit When used for detecting biochemical substances having a fluorescence response property in a fluid sample, the system can solve the problems in prior art such as time consumption, large reagent and sample consumption, complex operation and the like, can realize fluorescence detection under various conditions, hasthe advantages of high integration, quick analysis, high flexibility, little sample consumption, simple operation, quantitative analysis, online real-time detection and the like, has a compiling control degree that allows for combined use with a computer, independent operation, and can be used as a sensor unit in a wireless sensor network

Integrated micro-fluidic chip system

The invention provides a seebeck coefficient measuring system, comprising a test sample platform, a temperature difference heating platform, a hot end sample placing platform, a cold end sample placing platform, a signal acquiring and processing system and a temperature control system, wherein the test sample platform is used for placing a to-be-tested sample and forming a predetermined temperature difference between two ends of the to-be-tested sample; the temperature difference heating platform comprises a temperature difference heating platform body, a hot end heating pillar and a cold end heating pillar, wherein the hot end heating pillar and the cold end heating pillar are arranged on the temperature difference heating platform body, the hot end heating pillar and the cold end heating pillar insulate heat from each other, and have respective heating systems, respectively; the hot end sample placing platform and the cold end sample placing platform are arranged on the hot end heating pillar and the cold end heating pillar, respectively, and are used for placing the hot end and the cold end of the to-be-tested sample; the signal acquiring and processing system is used for calculating the seebeck coefficient; and the temperature control system is used for controlling the temperature difference between two ends of the to-be-tested sample. The seebeck coefficient measuring system provided by the invention can realize the positive and negative temperature difference measurements of the sample.

Seebeck coefficient measuring system

The invention discloses a surface plasma resonance sensing chip and a preparation method and application thereof. The preparation method comprises the steps that firstly, a glass substrate is washed and then dried; secondly, a chromium film is prepared, a gold film is prepared on the chromium film, and a naked gold chip is obtained; thirdly, a solution containing modified bovine serum albumin is dropwise added, the whole chip is paved with the solution, the solution continues to be dropwise added until the whole chip is soaked, and after a sealed vibration reaction is carried out for 0.5-2 hours, washing and drying are carried out; fourthly, a mixed solution of NHS and EDC is dropwise added, the whole chip is paved with the mixed solution, the solution continues to be dropwise added until the whole chip is soaked, and after a sealed vibration reaction is carried out for 15 minutes to 1 hour, washing and drying are carried out; fifthly, a bromoacetic acid solution is dropwise added, the whole chip is paved with the bromoacetic acid solution, the bromoacetic acid solution continues to be added until the whole chip is soaked with the bromoacetic acid solution, after a sealed vibration reaction is carried out for 8-24 hours, washing and drying are carried out, and a blank chip is obtained. According to the preparation method, the surface plasma resonance sensing chip can be obtained within only 2 days and has better homogeneity than a traditional glucan chip which is prepared within 5 days.

Surface plasma resonance sensing chip and preparation method and application thereof

The invention provides a multichannel spectral detection system which comprises a multichannel spectral detection device and a multichannel chip, wherein the multichannel spectral detection device is provided with m*n arrays of basic detection units (m and n are integers larger than 1 and represent the row and the line of each basic detection unit respectively); the multichannel chip is provided with multiple channels; each basic detection unit comprises a red-light LED light source, a green-light LED light source, a blue-light LED light source and a photodetector; emitted light with different colors is mixed by controlling the luminance of the red-light LED light sources, the green-light LED light sources and the blue-light LED light sources and emitted to a to-be-detected channel selected by a user; the photodetectors are used for detecting the intensity of reflected light reflected by to-be-detected samples added in the channels and outputting current or voltage signals used for generating spectral response; and during mounting, the multichannel chip is placed right above the multichannel spectral detection device, and each channel corresponds to one basic detection unit.

Multichannel spectral detection system and detection method thereof

The invention discloses a micro-fluidic chip system which comprises a micro-fluidic chip and a temperature control module. The micro-fluidic chip comprises a substrate, a structural piece and a cover piece. The substrate is located at the bottom of the micro-fluidic chip. The structural piece is arranged on the substrate and comprises a reaction pool. The cover piece is configured to cover the structural piece, a sealing cavity is formed between the cover piece and the structural piece, the reaction pool is located under the sealing cavity and a paraffin section is cured on the side, forming the sealing cavity, of the cover piece. The temperature control module is configured to be fixed to the micro-fluidic chip and used for heating and carrying out temperature measurement and control on reactants in the reaction pool. In addition, the system may further comprise a detection module. The micro-fluidic chip system can achieve quantitative detection and qualitative detection for isothermal amplification.

Micro-fluidic chip system and method for carrying out isothermal amplification and detection through same

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