Li Yang
5 Papers
Li Yang is an academic researcher. The author has contributed to research in topics: Tumor necrosis factor alpha & THP1 cell line. The author has an hindex of 5, co-authored 5 publications.
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Papers
Polo-Like Kinase 1 (PLK1) Is Involved in Toll-like Receptor (TLR)-Mediated TNF-α Production in Monocytic THP-1 Cells
TL;DR: It is suggested that PLK1 is involved in TLR2- and TLR4-induced inflammation, and GW843682X may be valuable for the regulation of the inflammatory response.
TNF-α-Induced NOD2 and RIP2 Contribute to the Up-Regulation of Cytokines Induced by MDP in Monocytic THP-1 Cells.
TL;DR: It is suggested that TNF‐α is a positive regulator for NOD2 functions via up‐regulation of N OD2 and its signal adaptor RIP2, and TNF•α‐induced A20 does not regulate MDP‐induced inflammatory responses in THP‐1 cells.
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A20 Is Critical for the Induction of Pam3CSK4-Tolerance in Monocytic THP-1 Cells
TL;DR: It is reported that TLR1/2 ligand Pam3CSK4 induced tolerance in monocytic THP-1 cells, and pharmacologic inhibition of GSK3 signaling down-regulated A20 expression, up-regulated Pam3 CSK4-induced inflammatory responses, and partly reversed Pam3csK4 pre-treatment-induced tolerance, suggesting that G SKS3 is involved in TLR 1/2-inducedolerance by up-regulation of A20expression.
Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells
TL;DR: The activation of TLR4 induced dose- and time-dependent cell death in moncytic THP-1 cells and TAP63α may be a target for the prevention of LPS-induced cell death, suggesting the involvement of intrinsic and extrinsic apoptosis pathways.
IL-1α and IL-1β promote NOD2-induced immune responses by enhancing MAPK signaling.
Sushan Li,Sushan Li,Ping Deng,Manzhi Wang,Xueting Liu,Manli Jiang,Binyuan Jiang,Li Yang,Jinyue Hu +8 more
TL;DR: IL-1α/β promote the NOD2-induced immune responses by enhancing MDP-induced activation of MAPK signaling pathways.