8 Papers
6 Citations
Li Y is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & Biodiversity. The author has an hindex of 3, co-authored 8 publications. Previous affiliations of Li Y include Kunming Institute of Zoology & Beth Israel Deaconess Medical Center.
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Papers
Fast Transport of RNA Granules by Direct Interactions with KIF5A/KLC1 Motors Prevents Axon Degeneration
Yusuke Fukuda,Maria F. Pazyra-Murphy,Ozge E. Tasdemir-Yilmaz,Li Y,Lynda M. Rose,Zoe C. Yeoh,Nicholas E. Vangos,Ezekiel A. Geffken,Hyuk-Soo Seo,Guillaume Adelmant,Bird Gh,Loren D. Walensky,Jarrod A. Marto,Sirano Dhe-Paganon,Rosalind A. Segal +14 more
TL;DR: It is demonstrated that a complex containing RNA and the RNA-binding protein SFPQ interacts directly with a tetrameric kinesin containing the adaptor KLC1 and the motor KIF5A and that replacing axonally translated proteins provides a therapeutic approach to axonal degenerative disorders.
Agent-based models reveal limits of mark-release-recapture estimates for the rare butterfly, Bhutanitis thaidina (Lepidoptera: Papilionidae).
TL;DR: In this article, the authors conducted a three-year MRR study of B. thaidina in Yanzigou valley, Mt. Gongga, and concluded that subjective decisions in sampling protocol (e.g., frequency, number of sampling locations, use of spatially explicit models, type of estimands) accounted for nearly half of the variation in estimates.
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FGFR inhibitor mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance
Li Y,Xintao Qiu,Xiaoqing Wang,Hui Liu,Renee C. Geck,Alok K. Tewari,Tengfei Xiao,Alba Font-Tello,Kah-Leong Lim,J. L. Kristen,M. Morrow,Raga Vadhi,Pei-Lun Kao,Aliya Jaber,Smitha Yerrum,Yingtian Xie,Kin-Hoe Chow,Paloma Cejas,Quang-Dé Nguyen,Henry W. Long,Xiaole Shirley Liu,Alex Toker,Alex Toker,Myles Brown +23 more
TL;DR: In this article, an epigenetic mechanism leading to the adaptive resistance of triple-negative breast cancer (TNBC) to fibroblast growth factor receptor (FGFR) inhibitors is reported.
Activation of Sarm1 produces cADPR to increase intra-axonal calcium and promote axon degeneration in CIPN
Li Y,Maria F. Pazyra-Murphy,Daina Avizonis,Russo MdST,Stephanie Tang,Johann Bergholz,Johann Bergholz,Tao Jiang,Jiangning Zhao,Jiangning Zhao,Jiang Zhu,Kwang Woo Ko,Jeffrey Milbrandt,Aaron DiAntonio,Rosalind A. Segal +14 more
TL;DR: In this paper, the authors demonstrate that paclitaxel triggers Sarm1-dependent cADPR production in distal axons, promoting intra-axonal calcium flux from both intracellular and extracellular calcium stores.
Measuring protected-area outcomes with leech iDNA: large-scale quantification of vertebrate biodiversity in Ailaoshan reserve
Yinqiu Ji,Christopher C. M. Baker,Li Y,Viorel D. Popescu,Zhengyang Wang,Jiaxin Wang,Lin Wang,Chunying Wu,Chaolang Hua,Zhongxin Yang,Chunyan Yang,Charles C.Y. Xu,Qingzhong Wen,Naomi E. Pierce,Douglas W. Yu +14 more
TL;DR: Vertebrate occupancies are a granular, large-scale conservation-outcome measure that can be used to increase management effectiveness and thus to improve the contributions that protected areas make to achieving global biodiversity goals.