Li-Xia Pan
Tsinghua University
4 Papers
15 Citations
Li-Xia Pan is an academic researcher from Tsinghua University. The author has contributed to research in topics: Histone H1 & Stem cell. The author has an hindex of 4, co-authored 4 publications.
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Papers
Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.
Li-Xia Pan,Wenbing Xie,Kai Le Li,Zhihao Yang,Jiang Xu,Wen-Hao Zhang,Lu Ping Liu,Xingjie Ren,Zhimin He,Junyu Wu,Jin Sun,Hui Min Wei,Da-Liang Wang,Wei Xie,Wei Li,Jian-Quan Ni,Fang-Lin Sun,Fang-Lin Sun +17 more
TL;DR: It is shown that cyclin-dependent kinase 12 (CDK12), a transcription elongation-associated RNA polymerase II (RNAPII) kinase, antagonizes heterochromatin enrichment in Drosophila chromosomes, which defines a previously unidentified role of CDK12 in controlling the epigenetic transition between euchromatin and heterochromaatin and suggest a chromatin regulatory mechanism in neuronal behaviors.
22
JMJD5 (Jumonji Domain-containing 5) Associates with Spindle Microtubules and Is Required for Proper Mitosis.
Zhimin He,Junyu Wu,Xiaonan Su,Ye Zhang,Li-Xia Pan,Hui-Min Wei,Qiang Fang,Haitao Li,Da-Liang Wang,Fang-Lin Sun,Fang-Lin Sun +10 more
TL;DR: The results suggest that JMJD5 plays an important role in regulating mitotic progression, probably by modulating the stability of spindle microtubules.
21
Histone H1 defect in escort cells triggers germline tumor in Drosophila ovary
Zhihao Yang,Jin Sun,Yuzhao Hu,Fang Wang,Xia Wang,Huan-Huan Qiao,Jiang Xu,Decai Mao,Xingjie Ren,Li-Xia Pan,Rong-Gang Xu,Bowen Xu,Yifan Zhang,Haiyi Li,Wei Miao,Yanhui Hu,Zhijie Chang,Dong Wang,Haitao Li,Zai Chang,Lu-Ping Liu,Qingfei Liu,Jian-Quan Ni +22 more
TL;DR: It is found that histone H1 depletion in escort cells (ECs) resulted in an increase of spectrosome-containing cells (SCCs), an ovary tumor-like phenotype, and double knockdown of H1 and dpp in ECs can reduce the number of SCCs to the normal level, indicating that the additional Dpp secreted by ECs contributes to the germline tumor.
16
Histone H1-mediated epigenetic regulation controls germline stem cell self-renewal by modulating H4K16 acetylation.
Jin Sun,Hui-Min Wei,Jiang Xu,Jiang Xu,Jian-Feng Chang,Zhihao Yang,Xingjie Ren,Wen-Wen Lv,Lu-Ping Liu,Li-Xia Pan,Xia Wang,Huan-Huan Qiao,Bing Zhu,Jun-Yuan Ji,Dong Yan,Ting Xie,Fang-Lin Sun,Jian-Quan Ni +17 more
TL;DR: It is reported that H1 is intrinsically required in the regulation of germline stem cells (GSCs) in the Drosophila ovary and functions intrinsically to promote GSC self-renewal by antagonizing MOF function.