To study the clinical value of 3.0T magnetic resonance whole heart coronary angiography in the diagnosis ofcoronary artery stenosis. 38 patients with suspected coronary artery stenosis were randomly selected from ourhospital from September 2017 to September 2018. All patients were diagnosed with whole heart coronaryangiography by 3.0T magnetic resonance examination. Angiography was adopted as the gold standard toevaluate the value of whole heart coronary angiography via 3.0T magnetic resonance. All the 38 patients havecompleted the examinations, including 13 segments with grade 0 image quality and 28 segments with grade Iimage quality. Of 38 patients, 25 underwent coronary angiography, 29 of 25 patients had coronary arterystenosis, while 30 of 25 patients had coronary artery stenosis.The results of 22 coronary stenoses which wereconfirmed by coronary angiography are consistent with the results obtained from whole heart coronary stenosisby 3.0T MRI. The accuracy, sensitivity, specificity, negative predictive value and positive predictive value of theimaging scheme were 75.86%, 75.86%, 96.67%, 73.33% and 80.00%, respectively.The 3.0T MR whole heartcoronary angiography is of outstanding value in the diagnosis of coronary artery stenosis and is worthy ofutilization

Application and Clinical Value of 3.0T Magnetic Resonance Whole Heart Coronary Angiography in the Diagnosis of Coronary Artery Stenosis

The combination of phosphorothioate-modified primer and high-fidelity DNA polymerase constitute a mutation sensitive on/off switch. Herein, a modified mutation-sensitive on/off switch was designed with an extra point mutation at 5′ far away from the 3′ of the phosphorothioate\n modified primer to test the power of the new enzymes: Phusion, Q5 and Phanta UC polymerases. A modified on/off switch with the introduction of an extra point mismatched nucleotide at –8 from the 3′ terminus, and the use of Phanta UC Super-fidelity DNA polymerase has been confirmed\n to be highly sensitive and specific as compared to those without the 5′ artificial mismatched nucleotide, when applied in circulating tumor DNA (ctDNA) analysis of BRAF hotspot mutation.

A Modified Mutation-Sensitive On/Off Switch and Its Application in B-Raf Proto-Oncogene Hotspot Mutation Assay

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A Modified Mutation-Sensitive On/Off Switch and Its Application in B-Raf Proto-Oncogene Hotspot Mutation Assay