Li-Sha Wang
Peking Union Medical College
21 Papers
54 Citations
Li-Sha Wang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Metabolite. The author has an hindex of 10, co-authored 20 publications.
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Papers
LC-MS/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice
Li-Sha Wang,Meng-Di Zhang,Xue Tao,Yun-Feng Zhou,Xinmin Liu,Ruile Pan,Yong-Hong Liao,Qi Chang +7 more
TL;DR: It was found that Kyn and 3-HK pathways were enhanced by CMS, while the levels of Trp, Kyna, 5-HIAA, Glu, GABA and ACh were significantly reduced, and changes in 5-HT and NE levels were not uniform in the periphery and the brain.
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Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice.
Xue Tao,Mingzhu Yan,Li-Sha Wang,Yun-Feng Zhou,Zhi Wang,Tianji Xia,Xinmin Liu,Ruile Pan,Qi Chang +8 more
TL;DR: It was speculated that the homeostasis of different glial cells could lead to a non-linear dose-dependent behavior by regulating the KYN pathway in the LPS-induced depressive-like mice.
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LC/MS-based metabolomics strategy to assess the amelioration effects of ginseng total saponins on memory deficiency induced by simulated microgravity
Li Feng,Xiao-fei Yue,Yi-xi Chen,Xinmin Liu,Li-Sha Wang,Fang-Rui Cao,Qiong Wang,Yong-Hong Liao,Ruile Pan,Qi Chang +9 more
TL;DR: GTS exhibits memory-improving effects mainly through regulating the metabolism of amino acids, neurotransmitters, choline, kynurenine, and sphingolipids, which can deepen the understanding of the underlying molecular mechanisms of MG-induced memory disorders.
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Pharmacokinetics of Nuciferine and N-Nornuciferine, Two Major Alkaloids From Nelumbo nucifera Leaves, in Rat Plasma and the Brain.
TL;DR: The plasma and brain pharmacokinetics of the two compounds were investigated after oral and intravenous administration of a lotus leaf alkaloid fraction to SD rats via ultra-performance liquid chromatography coupled with photodiode array detection and brain microdialysis to better understand the characteristics and neuro-pharmacological effects of the lotus alkaloids.
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Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine.
Yun-Feng Zhou,Xue Tao,Zhi Wang,Li Feng,Li-Sha Wang,Xinmin Liu,Ruile Pan,Yong-Hong Liao,Qi Chang +8 more
TL;DR: It is indicated that OBX caused marked abnormalities in hippocampus metabolites and autophagy, and fluoxetine could partly redress the metabolic disturbance and enhance autophagic to reverse the depressive-like behavior, but not the memory deficits in OBX rats.
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