5 Papers
11 Citations
Li Qiu is an academic researcher from Tianjin Medical University Cancer Institute and Hospital. The author has contributed to research in topics: Gene & Promoter. The author has an hindex of 4, co-authored 5 publications.
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Papers
FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage
TL;DR: K48-linkage-independent non-linear polyubiquitination of p53 as a new barcode for p53 activation and FATS promotes p53-dependent transcription of p21, leading to robust checkpoint response.
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FATS is a transcriptional target of p53 and associated with antitumor activity
X Zhang,Qian Zhang,Jun Zhang,Li Qiu,Shuangshuang Yan,Juling Feng,Yan Sun,Xingxu Huang,Karen H. Lu,Zheng Li +9 more
TL;DR: A novel transcript variant of FATS is identified through screening a cDNA library from mouse testis, which uncovered the promoter region of mouse FATS, and results reveal FATS as a p53-regulated gene to monitor genomic stability.
FATS expression is associated with cisplatin sensitivity in non small cell lung cancer.
TL;DR: Extensive expression of FATS significantly sensitized NSCLC cells to cisplatin-induced apoptosis and provides a new biomarker for a good outcome in patients receiving cisPlatin-based chemotherapy.
13
Efficient targeting of FATS at a common fragile site in mice through TALEN-mediated double-hit genome modification
TL;DR: The study indicates that the double-hit TALEN approach enhances targeting efficiency in vivo and provides convenience for monitoring germline transmission of mutations by PCR, which will facilitate the functional research on fragile-site genes.
11
A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women.
TL;DR: The finding that CT or TT genotype was significantly associated with a protective effect on breast cancer risk in women with parity ≥ 3, which was not affected by family history was found to suggest the role of FATS-p53 signaling cascade in suppressing pregnancy-related carcinogenesis and potential application in breast cancer prevention.