6 Papers
122 Citations
Li Ma is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Neutralizing antibody & Antibody. The author has an hindex of 6, co-authored 6 publications.
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Papers
Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus
Lu Deng,Lilin Zhong,Evi Struble,Hongying Duan,Li Ma,Christine Harman,Hailing Yan,Maria Luisa Virata-Theimer,Zhong Zhao,Stephen M. Feinstone,Harvey J. Alter,Pei Zhang +11 more
TL;DR: Structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine.
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Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization.
Lu Deng,Li Ma,Maria Luisa Virata-Theimer,Lilin Zhong,Hailing Yan,Zhong Zhao,Evi Struble,Stephen Feinstone,Harvey J. Alter,Pei Zhang +9 more
TL;DR: X-ray crystallographic analysis revealed that one of the critical antibody-binding sites on the hepatitis C virus exists in different shapes and is governed by a highly conserved glycine residue that serves as a flexible joint connecting the two essential parts of the binding site.
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A neutralization epitope in the hepatitis C virus E2 glycoprotein interacts with host entry factor CD81.
Zhong Zhao,Lilin Zhong,Elizabeth Elrod,Evi Struble,Li Ma,Hailing Yan,Christine Harman,Lu Deng,Maria Luisa Virata-Theimer,Peter Liu,Harvey J. Alter,Arash Grakoui,Pei Zhang +12 more
TL;DR: It is demonstrated here that 1H8 recognized an epitope mapped between residues A524 and W529 of the E2 protein that neutralizes HCV in vitro, and the characterization of this neutralization epitope with a function in host entry factor CD81 interaction should enhance the understanding of antibody-mediated neutralization of HCV infections.
Transplacental Transfer of Hepatitis B Neutralizing Antibody during Pregnancy in an Animal Model: Implications for Newborn and Maternal Health
TL;DR: It was shown that nAb transferred transplacentally from the pregnant guinea pigs to their litters; no transfer occurred during parturition, and the amount of the transferred nAb was dose and time dependent.
Parvovirus B19 infection transmitted by transfusion of red blood cells confirmed by molecular analysis of linked donor and recipient samples.
Mei-ying W. Yu,Harvey J. Alter,Maria Luisa Virata-Theimer,Yansheng Geng,Li Ma,Cathy Schechterly,Camilla Colvin,Naomi L.C. Luban +7 more
TL;DR: Paired donor‐recipient samples were used to investigate the transfusion risk and found extremely high viremic levels of parvovirus B19 (B19V) in acutely infected, but asymptomatic donors.