for Diagnostics and Therapeutics Sunaina Singh,*,†,∥ Amit Aggarwal,*,†,∥ N. V. S. Dinesh K. Bhupathiraju,*,‡ Gianluca Arianna,‡ Kirran Tiwari,‡ and Charles Michael Drain‡,§ †Department of Natural Sciences, LaGuardia Community College of the City University of New York, Long Island City, New York 11101, United States ‡Department of Chemistry and Biochemistry, Hunter College of the City University of New York, New York, New York 10065, United States The Rockefeller University, New York, New York 10065, United States

Glycosylated Porphyrins, Phthalocyanines, and Other Porphyrinoids for Diagnostics and Therapeutics.

Non-invasive monitoring of gastrointestinal drug release in vivo is extremely challenging because of the limited spatial resolution and long scanning time of existing bioimaging modalities, such as X-ray radiation and magnetic resonance. Here, we report a novel microcarrier that can retain drugs and withstand the harsh conditions of gastrointestinal tract. Significantly, we can track the microcarrier fate and semi-quantitatively monitor the content of drug released in vivo in real time by measuring the fluorescence signals in the second near-infrared window of lanthanide-based downconversion nanoparticles with an absorption competition-induced emission bioimaging system. The microcarriers show a prolonged residence time of up to 72 h in the gastrointestinal tract, releasing up to 62% of their content. Moreover, minimal deposition of the microcarriers is found in non-target organs, such as the liver, spleen and kidney. These findings provide novel insights for the development of therapeutic and bioimaging strategies of orally administered drugs.

/pdf/in-vivo-gastrointestinal-drug-release-monitoring-through-2r9wvsqknc.pdf

In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers

Recent advances in porphyrin-based nanocomposites for effective targeted imaging and therapy

The following article is the first attempt to investigate the supramolecular structure of cellulose with the varied moisture content by the means of Fourier-transform and near infrared spectroscopy techniques. Moreover, authors aimed at the detailed and precise presentation of IR spectra interpretation approach in order to create a reliable guideline for other researchers. On the basis of obtained data, factors indicating biopolymer crystallinity and development of hydrogen interactions were calculated and the peaks representing hydrogen bonding (7500-6000 cm-1, 3700-3000 cm-1, and 1750-1550 cm-1) were resolved using the Gaussian distribution function. Then, the deconvoluted signals have been assigned to the specific interactions occurring at the supramolecular level and the hydrogen bond length, as well bonding-energy were established. Furthermore, not only was the water molecules adsorption observed, but also the possibility of the 3OH⋯O5 intramolecular hydrogen bond shortening in the wet state was found-from (27,786 ± 2) 10-5 nm to (27,770 ± 5) 10-5 nm. Additionally, it was proposed that some deconvoluted signals from the region of 3000-2750 cm-1 might be assigned to the hydroxyl group-incorporated hydrogen bonding, which is, undoubtedly, a scientific novelty as the peak was not resolved before.

https://www.mdpi.com/1996-1944/13/20/4573/pdf

IR Study on Cellulose with the Varied Moisture Contents: Insight into the Supramolecular Structure.

Microwave-assisted multicomponent reactions for rapid synthesis of AIE-active fluorescent polymeric nanoparticles by post-polymerization method.

Fluorescent nanogel based on four-arm PEG-PCL copolymer with porphyrin core for bioimaging.

In order to develop a novel near infrared fluorescence agent, glucose conjugated zinc phthalocyanine, [2,9(10),16(17),23(24)-tetrakis((1-(β-D-glucopyranose-2-yl)-1H-1,2,3-triazol-4-yl)methoxyl)phthalocyaninato]zinc(II), was synthesized via Click reaction. Their chemical structures were characterized by mass spectrometry, nuclear magnetic resonance spectrum. Their light stability and fluorescence quantum yield were evaluated by UV-visible and fluorescent spectroscopic method. Optical imaging in vivo was performed with this saccharide conjugated phthalocyanine as probe on liver tumor-bearing nude mice. Near-infrared imaging effect, organ aggregation as well as distribution of probe in vivo were evaluated by in vivo fluorescence imaging technique. Results show that glucose conjugated zinc phthalocyanine has favorable water solubility, good optical stability and high emission ability in near infrared region. Imaging results demonstrate that saccharide conjugated phthalocyanine has possess obvious imaging effect in vivo, which implies its potential in cancer diagnosis as near infrared optical probe.

Synthesis, properties and near-infrared imaging evaluation of glucose conjugated zinc phthalocyanine via Click reaction

pH-labile artificial natural killer cells for overcoming tumor drug resistance.

Saccharide-substituted zinc phthalocyanines, [2,9(10),16(17),23(24)-tetrakis((1-(β-D-glucose-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)phthalocyaninato]zinc(II) and [2,9(10), 16(17),23(24)-tetrakis((1-(β-D-lactose-2-yl)-1H-1,2,3-triazol-4-yl)methoxy)phthalocyaninato] zinc(II), were evaluated as novel near infrared fluorescence agents. Their interaction with bovine serum albumin was investigated by fluorescence and circular dichroism spectroscopy and isothermal titration calorimetry. Near infrared imaging for sentinel lymph nodes in vivo was performed using nude mice as models. Results show that saccharide- substituted zinc phthalocyanines have favourable water solubility, good optical stability and high emission ability in the near infrared region. The interaction of lactose-substituted phthalocyanine with bovine serum albumin displays obvious differences to that of glucose- substituted phthalocyanine. Moreover, lactose-substituted phthalocyanine possesses obvious imaging effects for sentinel lymph nodes in vivo.

https://www.mdpi.com/1420-3049/19/1/525/pdf

Saccharide substituted zinc phthalocyanines: optical properties, interaction with bovine serum albumin and near infrared fluorescence imaging for sentinel lymph nodes.

A simple novel near-infrared water-soluble glucose-conjugated porphyrin, 5,15-bis-[(trimethylsilyl)ethynyl]-10,20-bis[4-β-D-glucopyranosyl)phenyl]porphyrin, with good optical stability and high emission ability in near-infrared region, was synthesized. And Optical Imaging in vivo with this compound as probe was performed on liver tumor-bearing nude mice. The result shows that this glucose-conjugated porphyrin could display information in vivo more than 1 cm in depth, which implies its potential application as optical probe in cancer diagnosis.

A novel water-soluble near-infrared glucose-conjugated porphyrin: synthesis, properties and its optical imaging effect

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