Li Liu
University of Washington
4 Papers
24 Citations
Li Liu is an academic researcher from University of Washington. The author has contributed to research in topics: Erythropoiesis & Haematopoiesis. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Li Liu include Fred Hutchinson Cancer Research Center.
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Papers
Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver.
Sioban Keel,Raymond T. Doty,Li Liu,Elizabeta Nemeth,Sindhu Cherian,Tomas Ganz,Janis L. Abkowitz +6 more
TL;DR: The characterization of erythropoiesis, iron status, and hepcidin expression in mice with global or hematopoietic cell-specific haploinsufficiency of transferrin receptor 1 provides initial supporting data for this model, supporting the concept that several mechanisms signal iron need in response to an expanded erythron.
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Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development
TL;DR: It is discovered that mice lacking PiT1 develop a profound underproduction anemia characterized by mild macrocytosis, dyserythropoiesis, increased apoptosis, and a near complete block in terminal erythroid differentiation, and the animals are severely B cell lymphopenic because of a defect in pro-B cell development and mildly neutropenic.
Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome
Zhantao Yang,Sioban Keel,Akiko Shimamura,Akiko Shimamura,Li Liu,Aaron T. Gerds,Henry Y. Li,Brent L. Wood,Bart L. Scott,Janis L. Abkowitz +9 more
TL;DR: It is demonstrated that erythropoiesis fails when heme exceeds globin, and therapies that decrease heme synthesis (or facilitate heme export) could improve the red blood cell production of persons with DBA, del(5q) MDS, and perhaps other macrocytic anemias.
Single-cell analyses demonstrate that a heme–GATA1 feedback loop regulates red cell differentiation
Raymond T. Doty,Xiaowei Yan,Christopher Lausted,Adam D. Munday,Zhantao Yang,Danielle Yi,Neda Jabbari,Li Liu,Sioban Keel,Qiang Tian,Janis L. Abkowitz +10 more
TL;DR: Observations reveal a GATA1-heme autoregulatory loop and implicate GATA2 and heme as the comaster regulators of the normal erythroid differentiation program, and may help explain the ineffective (early termination of) erythropoiesis in Diamond Blackfan anemia and del(5q) myelodysplasia.