5 Papers
12 Citations
Li Li is an academic researcher from Capital Medical University. The author has contributed to research in topics: Lipid droplet & Fatty liver. The author has an hindex of 3, co-authored 3 publications.
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Papers
F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation.
TL;DR: It is shown that Smurf1 is an endogenous substrate of Fbxo3, belonging to the FBXO type protein family, and gains further insight into the novel role of F bxo2 in BMP signaling.
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Mechanism of the effect of glycosyltransferase GLT8D2 on fatty liver
Yu-Tao Zhan,Fei Zhao,Ping Xie,Le-Ping Zhong,Dongnian Li,Qujing Gai,Li Li,Hong-Shan Wei,Lingqiang Zhang,Wei An +9 more
TL;DR: GLT8D2 participated in NAFLD pathogenesis possibly by negatively regulating MTP expression, and specific inhibition of GLT8d2 via an antagonistic strategy could provide a potential candidate approach for treatment ofNAFLD.
Deficiency of CKIP-1 aggravates high-fat diet-induced fatty liver in mice
TL;DR: It is indicated that CKIP‐1 deficiency in mice aggravates HFD‐induced fatty liver by upregulating JNK1 phosphorylation and further up Regulating IRS‐1 phosphORYlation and RI.
13
Deletion of Smurf1 attenuates liver steatosis via stabilization of p53.
TL;DR: This study shows that Smurf1 is involved in the pathogenesis of NAFLD by balancing de novo lipid synthesis and lipolysis by interacting with and stabilizing mouse double minute 2 (MDM2) and promoting p53 degradation.
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Deletion of Smurf1 attenuates liver steatosis via stabilization of p53
TL;DR: This study shows that Smurf1 is involved in the pathogenesis of NAFLD by balancing de novo lipid synthesis and lipolysis by balancing p53 ubiquitynation via stabilizing mouse double minute 2 (MDM2).